Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways

Sodium fluoride (NaF) is used as a source of fluoride ions in diverse applications. Fluoride salt is an effective prophylactic for dental caries and is an essential element required for bone health. However, fluoride is known to cause cytotoxicity in a concentration-dependent manner. Further, no inf...

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Veröffentlicht in:	Toxicology and applied pharmacology 2012-03, Vol.259 (3), p.329-337
Hauptverfasser:	Nguyen Ngoc, Tam Dan, Son, Young-Ok, Lim, Shin-Saeng, Shi, Xianglin, Kim, Jong-Ghee, Heo, Jung Sun, Choe, Youngji, Jeon, Young-Mi, Lee, Jeong-Chae
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ADP Animals APOPTOSIS Apoptosis - drug effects Biological and medical sciences CALCIUM IONS Cariostatic Agents - administration & dosage Cariostatic Agents - toxicity CATALASE Catalase - metabolism CATS Cell death Cell Survival - drug effects Cellular signaling DNA - biosynthesis DNA - drug effects Dose-Response Relationship, Drug ELECTRON SPIN RESONANCE Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism G2 Phase Cell Cycle Checkpoints - drug effects Hydroxyl Radical - metabolism IODIDES JNK Mitogen-Activated Protein Kinases - metabolism M Phase Cell Cycle Checkpoints - drug effects Medical sciences Membrane Potential, Mitochondrial - drug effects MICE MITOCHONDRIA Mouse embryonic stem cells OXYGEN Reactive Oxygen Species - metabolism RIBOSE ROS Sodium fluoride Sodium Fluoride - administration & dosage Sodium Fluoride - toxicity SODIUM FLUORIDES STEM CELLS SUPEROXIDE DISMUTASE TETRAZOLIUM Toxicology
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