Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation

Although sunlight is known to induce skin lesions in patients with systemic lupus erythematosus (SLE) and to exacerbate systemic manifestations, the underlying mechanisms remain obscure. We report experiments that show enhanced binding of IgG autoantibodies to the cell surface membrane of ultraviole...

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Veröffentlicht in:	The Journal of clinical investigation 1992-09, Vol.90 (3), p.1067-1076
Hauptverfasser:	Golan, T D, Elkon, K B, Gharavi, A E, Krueger, J G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Surface - analysis Autoantibodies - immunology Autoantigens - analysis Cell Survival - radiation effects Cells, Cultured Female Humans Keratinocytes - immunology Keratinocytes - radiation effects Lupus Erythematosus, Systemic - immunology Male Middle Aged Ultraviolet Rays - adverse effects
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