Molecular Mechanochemistry: Low Force Switch Slows Enzymatic Cleavage of Human Type I Collagen Monomer

In vertebrate animals, fibrillar collagen accumulates, organizes, and persists in structures which resist mechanical force. This antidissipative behavior is possibly due to a mechanochemical force-switch which converts collagen from enzyme-susceptible to enzyme-resistant. Degradation experiments on...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-03, Vol.133 (11), p.4073-4078
Hauptverfasser:	Camp, Robert J, Liles, Melody, Beale, John, Saeidi, Nima, Flynn, Brendan P, Moore, Elias, Murthy, Shashi K, Ruberti, Jeffrey W
Format:	Artikel
Sprache:	eng
Schlagworte:	Collagen Type I - chemistry Collagen Type I - metabolism Humans Hydrolysis Kinetics
Online-Zugang:	Volltext
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