TNF superfamily in inflammatory disease: translating basic insights
The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of approximately 50 membrane and soluble proteins that can modulate cellular function. Most of these molecules are expressed by or can target cells of the immune system, and they have a wide range of actions in...
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| Veröffentlicht in: | Trends in immunology 2012-03, Vol.33 (3), p.144-152 |
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| creator | Croft, Michael Duan, Wei Choi, Heonsik Eun, So-Young Madireddi, Shravan Mehta, Amit |
| description | The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of approximately 50 membrane and soluble proteins that can modulate cellular function. Most of these molecules are expressed by or can target cells of the immune system, and they have a wide range of actions including promoting cellular differentiation, survival, and production of inflammatory cytokines and chemokines. Emerging data show that TNFSF ligand–receptor signaling pathways are active in inflammatory and autoimmune disease. Furthermore, several genetic polymorphisms in TNFSF and TNFRSF associate with susceptibility to developing disease. Here, we examine recent data regarding the potential of these molecules as targets for therapy of autoimmune and inflammatory disease. |
| doi_str_mv | 10.1016/j.it.2011.10.004 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Animals Atherosclerosis Autoimmune diseases Autoimmune Diseases - immunology Cell division chemokines Clinical trials Diabetes Disease genetic polymorphism Humans Immune system Inflammation - immunology Inflammatory bowel disease Ligands Lupus Lymphocytes Lymphoma Mortality proteins Receptors, Tumor Necrosis Factor - immunology Sepsis signal transduction Studies therapeutics TNF inhibitors tumor necrosis factors Tumor Necrosis Factors - immunology |
| title | TNF superfamily in inflammatory disease: translating basic insights |
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