Recognition by recombinant autoimmune thyroid disease-derived fab fragments of a dominant conformational epitope on human thyroid peroxidase

To characterize the nature of thyroid peroxidase (TPO) autoantibodies present in the sera of patients with autoimmune thyroid disease, we cloned three IgG1/kappa Fab fragments which bind 125I-TPO. This was accomplished by the molecular cloning and expression in bacteria of IgG gene fragments from B...

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Veröffentlicht in:	The Journal of clinical investigation 1992-09, Vol.90 (3), p.720-726
Hauptverfasser:	PORTOLANO, S, CHAZENBALK, G. D, SETO, P, HUTCHISON, J. S, RAPOPORT, B, MCLACHLAN, S. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Autoantibodies - immunology Autoimmune Diseases - immunology Base Sequence Biological and medical sciences Endocrinopathies Epitopes - analysis Humans Immunoglobulin Fab Fragments - immunology Iodide Peroxidase - immunology Medical sciences Molecular Sequence Data Recombinant Proteins - immunology Thyroid Diseases - immunology
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