Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis

The mitochondrial chaperone mortalin has been linked to neurodegeneration in Parkinson's disease (PD) based on reduced protein levels in affected brain regions of PD patients and its interaction with the PD-associated protein DJ-1. Recently, two amino acid exchanges in the ATPase domain (R126W)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2010-11, Vol.19 (22), p.4437-4452
Hauptverfasser:	Burbulla, Lena F., Schelling, Carina, Kato, Hiroki, Rapaport, Doron, Woitalla, Dirk, Schiesling, Carola, Schulte, Claudia, Sharma, Manu, Illig, Thomas, Bauer, Peter, Jung, Stephan, Nordheim, Alfred, Schöls, Ludger, Riess, Olaf, Krüger, Rejko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - metabolism Female Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Genetic Variation Genetics of eukaryotes. Biological and molecular evolution HSP70 Heat-Shock Proteins - genetics Humans Male Medical sciences Membrane Potential, Mitochondrial - genetics Middle Aged Mitochondria - metabolism Mitochondria - physiology Mitochondrial Proteins - metabolism Molecular and cellular biology Molecular Chaperones - genetics Neurology Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - physiopathology Reactive Oxygen Species - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!