Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway

The interference of the recombinant HIV-1 glycoproteins gp160 and gp120 with the CD3/T cell antigen receptor (TcR)-mediated activation process has been investigated in the CD4+ diphtheria toxoid-specific human P28D T cell clone. Both glycoproteins clearly inhibit the T cell proliferation induced in...

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Veröffentlicht in:	The Journal of clinical investigation 1990-12, Vol.86 (6), p.2117-2124
Hauptverfasser:	CEFAI, D, DEBRE, P, KACZOREK, M, IDZIOREK, T, AUTRAN, B, BISMUTH, G
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antigens, CD - physiology Antigens, Differentiation, T-Lymphocyte - physiology Biological and medical sciences Calcium - physiology CD2 Antigens CD3 Complex CD4-Positive T-Lymphocytes - physiology Clone Cells Gene Products, env - pharmacology HIV Envelope Protein gp120 - pharmacology HIV-1 - immunology Humans Hydrogen-Ion Concentration Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology In Vitro Techniques Lymphocyte Activation - drug effects Medical sciences Phosphatidylinositols - physiology Receptors, Antigen, T-Cell - physiology Receptors, Immunologic - physiology Signal Transduction - drug effects
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