Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors

Postnatal oligodendrocyte progenitor cells (OPC) self-renew, generate mature oligodendrocytes, and are a cellular origin of oligodendrogliomas. We show that the proteoglycan NG2 segregates asymmetrically during mitosis to generate OPC cells of distinct fate. NG2 is required for asymmetric segregatio...

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Veröffentlicht in:	Cancer cell 2011-09, Vol.20 (3), p.328-340
Hauptverfasser:	Sugiarto, Sista, Persson, Anders I., Munoz, Elena Gonzalez, Waldhuber, Markus, Lamagna, Chrystelle, Andor, Noemi, Hanecker, Patrizia, Ayers-Ringler, Jennifer, Phillips, Joanna, Siu, Jason, Lim, Daniel A., Vandenberg, Scott, Stallcup, William, Berger, Mitchel S., Bergers, Gabriele, Weiss, William A., Petritsch, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - genetics Antigens - metabolism Brain Cell Differentiation Cell Division Cell Proliferation Cell Transformation, Neoplastic Cells, Cultured ErbB Receptors - genetics ErbB Receptors - metabolism Glioma - genetics Glioma - metabolism Glioma - pathology Humans Mice Mice, Transgenic Mutation Oligodendroglia - cytology Oligodendroglia - metabolism Oligodendroglia - physiology Oligodendroglioma - pathology Proteoglycans - deficiency Proteoglycans - genetics Proteoglycans - metabolism Stem Cells - cytology Stem Cells - metabolism Stem Cells - physiology
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