Neurogenic Changes in the Upper Airway of Patients with Obstructive Sleep Apnea
Controversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA). We assessed quantitative parameters related to motor unit potential (MUP) morphology derived from electromyographic (EMG) signals in patients with OSA versus control subjects...
Gespeichert in:
| Veröffentlicht in: | American journal of respiratory and critical care medicine 2012-02, Vol.185 (3), p.322-329 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 329 |
|---|---|
| container_issue | 3 |
| container_start_page | 322 |
| container_title | American journal of respiratory and critical care medicine |
| container_volume | 185 |
| creator | SABOISKY, Julian P STASHUK, Daniel W NANDEDKAR, Sanjeev DAVID, William S MALHOTRA, Atul HAMILTON-WRIGHT, Andrew CARUSONA, Andrea L CAMPANA, Lisa M TRINDER, John ECKERT, Danny J JORDAN, Amy S MCSHARRY, David G WHITE, David P |
| description | Controversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA).
We assessed quantitative parameters related to motor unit potential (MUP) morphology derived from electromyographic (EMG) signals in patients with OSA versus control subjects and hypothesized that signs of neurogenic remodeling would be present in the patients with OSA.
Participants underwent diagnostic sleep studies to obtain apnea-hypopnea indices. Muscle activity was detected with 50-mm concentric needle electrodes. The concentric needle was positioned at more than 10 independent sites per subject, after the local anatomy of the upper airway musculature was examined by ultrasonography. All activity was quantified with subjects awake, during supine eupneic breathing while wearing a nasal mask connected to a pneumotachograph. Genioglossus EMG signals were analyzed offline by automated software (DQEMG), which extracted motor unit potential trains (MUPTs) contributed by individual motor units from the composite EMG signals. Quantitative measurements of MUP templates, including duration, peak-to-peak amplitude, area, area-to-amplitude ratio, and size index, were compared between the untreated patients with OSA and healthy control subjects.
A total of 1,655 MUPTs from patients with OSA (n = 17; AHI, 55 ± 6/h) and control subjects (n = 14; AHI, 4 ± 1/h) were extracted from the genioglossus muscle EMG signals. MUP peak-to-peak amplitudes in the patients with OSA were not different compared with the control subjects (397.5 ± 9.0 vs. 382.5 ± 10.0 μV). However, the MUPs of the patients with OSA were longer in duration (11.5 ± 0.1 vs. 10.3 ± 0.1 ms; P < 0.001) and had a larger size index (4.09 ± 0.02 vs. 3.92 ± 0.02; P < 0.001) compared with control subjects.
These results confirm and quantify the extent and existence of structural neural remodeling in OSA. |
| doi_str_mv | 10.1164/rccm.201106-1058OC |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3297112</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>919955483</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-e5834255cb9c91237ba334f0996dc7e490a6b8908bc7b7081abcdb1933973d9b3</originalsourceid><addsrcrecordid>eNpdkV9rFDEUxYMotq5-AR8kCMWnqbmTZCZ5EZZFW6G4ghZ8C0n2zm7KbGZMZlr67U3Ztf55yoX8zr3n3kPIa2DnAI14n7zfn9cMgDUVMKnWqyfkFCSXldAte1pq1vJKCP3jhLzI-YYxqBWw5-SkLqpGCHlK1l9wTsMWY_B0tbNxi5mGSKcd0utxxESXId3Zezp09KudAsYp07sw7eja5SnNfgq3SL_1iCNdjhHtS_Kss33GV8d3Qa4_ffy-uqyu1hefV8uryguppgql4qKW0jvtNdS8dZZz0TGtm41vUWhmG6c0U863rmUKrPMbB5pz3fKNdnxBPhz6jrPb48YXY8n2Zkxhb9O9GWww__7EsDPb4dbwWrdQJi7Iu2ODNPycMU9mH7LHvrcRhzkbDVpLKRQv5Nv_yJthTrFsZ3RdLqmKvQLVB8inIeeE3aMVYOYhLfOQljmkZQ5pFdGbv5d4lPyOpwBnR8Bmb_su2ehD_sNJyUBAw38BVXeeCQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>922208081</pqid></control><display><type>article</type><title>Neurogenic Changes in the Upper Airway of Patients with Obstructive Sleep Apnea</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>American Thoracic Society (ATS) Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>SABOISKY, Julian P ; STASHUK, Daniel W ; NANDEDKAR, Sanjeev ; DAVID, William S ; MALHOTRA, Atul ; HAMILTON-WRIGHT, Andrew ; CARUSONA, Andrea L ; CAMPANA, Lisa M ; TRINDER, John ; ECKERT, Danny J ; JORDAN, Amy S ; MCSHARRY, David G ; WHITE, David P</creator><creatorcontrib>SABOISKY, Julian P ; STASHUK, Daniel W ; NANDEDKAR, Sanjeev ; DAVID, William S ; MALHOTRA, Atul ; HAMILTON-WRIGHT, Andrew ; CARUSONA, Andrea L ; CAMPANA, Lisa M ; TRINDER, John ; ECKERT, Danny J ; JORDAN, Amy S ; MCSHARRY, David G ; WHITE, David P</creatorcontrib><description>Controversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA).
We assessed quantitative parameters related to motor unit potential (MUP) morphology derived from electromyographic (EMG) signals in patients with OSA versus control subjects and hypothesized that signs of neurogenic remodeling would be present in the patients with OSA.
Participants underwent diagnostic sleep studies to obtain apnea-hypopnea indices. Muscle activity was detected with 50-mm concentric needle electrodes. The concentric needle was positioned at more than 10 independent sites per subject, after the local anatomy of the upper airway musculature was examined by ultrasonography. All activity was quantified with subjects awake, during supine eupneic breathing while wearing a nasal mask connected to a pneumotachograph. Genioglossus EMG signals were analyzed offline by automated software (DQEMG), which extracted motor unit potential trains (MUPTs) contributed by individual motor units from the composite EMG signals. Quantitative measurements of MUP templates, including duration, peak-to-peak amplitude, area, area-to-amplitude ratio, and size index, were compared between the untreated patients with OSA and healthy control subjects.
A total of 1,655 MUPTs from patients with OSA (n = 17; AHI, 55 ± 6/h) and control subjects (n = 14; AHI, 4 ± 1/h) were extracted from the genioglossus muscle EMG signals. MUP peak-to-peak amplitudes in the patients with OSA were not different compared with the control subjects (397.5 ± 9.0 vs. 382.5 ± 10.0 μV). However, the MUPs of the patients with OSA were longer in duration (11.5 ± 0.1 vs. 10.3 ± 0.1 ms; P < 0.001) and had a larger size index (4.09 ± 0.02 vs. 3.92 ± 0.02; P < 0.001) compared with control subjects.
These results confirm and quantify the extent and existence of structural neural remodeling in OSA.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.201106-1058OC</identifier><identifier>PMID: 22016445</identifier><language>eng</language><publisher>New York, NY: American Thoracic Society</publisher><subject>Action Potentials ; Adult ; Airway Remodeling ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Case-Control Studies ; Electrodes ; Electromyography ; Emergency and intensive respiratory care ; Female ; Humans ; Hypoglossal Nerve - physiopathology ; Intensive care medicine ; Male ; Medical sciences ; Morphology ; Motor Neurons - physiology ; Muscle function ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiopathology ; Neurogenesis ; Pathogenesis ; Respiration ; Sleep apnea ; Sleep Apnea, Obstructive - physiopathology ; Tongue - physiopathology ; Ultrasonic imaging</subject><ispartof>American journal of respiratory and critical care medicine, 2012-02, Vol.185 (3), p.322-329</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Thoracic Society Feb 1, 2012</rights><rights>Copyright © 2012 by the American Thoracic Society 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-e5834255cb9c91237ba334f0996dc7e490a6b8908bc7b7081abcdb1933973d9b3</citedby><cites>FETCH-LOGICAL-c458t-e5834255cb9c91237ba334f0996dc7e490a6b8908bc7b7081abcdb1933973d9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4025,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25501416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22016445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SABOISKY, Julian P</creatorcontrib><creatorcontrib>STASHUK, Daniel W</creatorcontrib><creatorcontrib>NANDEDKAR, Sanjeev</creatorcontrib><creatorcontrib>DAVID, William S</creatorcontrib><creatorcontrib>MALHOTRA, Atul</creatorcontrib><creatorcontrib>HAMILTON-WRIGHT, Andrew</creatorcontrib><creatorcontrib>CARUSONA, Andrea L</creatorcontrib><creatorcontrib>CAMPANA, Lisa M</creatorcontrib><creatorcontrib>TRINDER, John</creatorcontrib><creatorcontrib>ECKERT, Danny J</creatorcontrib><creatorcontrib>JORDAN, Amy S</creatorcontrib><creatorcontrib>MCSHARRY, David G</creatorcontrib><creatorcontrib>WHITE, David P</creatorcontrib><title>Neurogenic Changes in the Upper Airway of Patients with Obstructive Sleep Apnea</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Controversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA).
We assessed quantitative parameters related to motor unit potential (MUP) morphology derived from electromyographic (EMG) signals in patients with OSA versus control subjects and hypothesized that signs of neurogenic remodeling would be present in the patients with OSA.
Participants underwent diagnostic sleep studies to obtain apnea-hypopnea indices. Muscle activity was detected with 50-mm concentric needle electrodes. The concentric needle was positioned at more than 10 independent sites per subject, after the local anatomy of the upper airway musculature was examined by ultrasonography. All activity was quantified with subjects awake, during supine eupneic breathing while wearing a nasal mask connected to a pneumotachograph. Genioglossus EMG signals were analyzed offline by automated software (DQEMG), which extracted motor unit potential trains (MUPTs) contributed by individual motor units from the composite EMG signals. Quantitative measurements of MUP templates, including duration, peak-to-peak amplitude, area, area-to-amplitude ratio, and size index, were compared between the untreated patients with OSA and healthy control subjects.
A total of 1,655 MUPTs from patients with OSA (n = 17; AHI, 55 ± 6/h) and control subjects (n = 14; AHI, 4 ± 1/h) were extracted from the genioglossus muscle EMG signals. MUP peak-to-peak amplitudes in the patients with OSA were not different compared with the control subjects (397.5 ± 9.0 vs. 382.5 ± 10.0 μV). However, the MUPs of the patients with OSA were longer in duration (11.5 ± 0.1 vs. 10.3 ± 0.1 ms; P < 0.001) and had a larger size index (4.09 ± 0.02 vs. 3.92 ± 0.02; P < 0.001) compared with control subjects.
These results confirm and quantify the extent and existence of structural neural remodeling in OSA.</description><subject>Action Potentials</subject><subject>Adult</subject><subject>Airway Remodeling</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Electrodes</subject><subject>Electromyography</subject><subject>Emergency and intensive respiratory care</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoglossal Nerve - physiopathology</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphology</subject><subject>Motor Neurons - physiology</subject><subject>Muscle function</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Neurogenesis</subject><subject>Pathogenesis</subject><subject>Respiration</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Tongue - physiopathology</subject><subject>Ultrasonic imaging</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkV9rFDEUxYMotq5-AR8kCMWnqbmTZCZ5EZZFW6G4ghZ8C0n2zm7KbGZMZlr67U3Ztf55yoX8zr3n3kPIa2DnAI14n7zfn9cMgDUVMKnWqyfkFCSXldAte1pq1vJKCP3jhLzI-YYxqBWw5-SkLqpGCHlK1l9wTsMWY_B0tbNxi5mGSKcd0utxxESXId3Zezp09KudAsYp07sw7eja5SnNfgq3SL_1iCNdjhHtS_Kss33GV8d3Qa4_ffy-uqyu1hefV8uryguppgql4qKW0jvtNdS8dZZz0TGtm41vUWhmG6c0U863rmUKrPMbB5pz3fKNdnxBPhz6jrPb48YXY8n2Zkxhb9O9GWww__7EsDPb4dbwWrdQJi7Iu2ODNPycMU9mH7LHvrcRhzkbDVpLKRQv5Nv_yJthTrFsZ3RdLqmKvQLVB8inIeeE3aMVYOYhLfOQljmkZQ5pFdGbv5d4lPyOpwBnR8Bmb_su2ehD_sNJyUBAw38BVXeeCQ</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>SABOISKY, Julian P</creator><creator>STASHUK, Daniel W</creator><creator>NANDEDKAR, Sanjeev</creator><creator>DAVID, William S</creator><creator>MALHOTRA, Atul</creator><creator>HAMILTON-WRIGHT, Andrew</creator><creator>CARUSONA, Andrea L</creator><creator>CAMPANA, Lisa M</creator><creator>TRINDER, John</creator><creator>ECKERT, Danny J</creator><creator>JORDAN, Amy S</creator><creator>MCSHARRY, David G</creator><creator>WHITE, David P</creator><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120201</creationdate><title>Neurogenic Changes in the Upper Airway of Patients with Obstructive Sleep Apnea</title><author>SABOISKY, Julian P ; STASHUK, Daniel W ; NANDEDKAR, Sanjeev ; DAVID, William S ; MALHOTRA, Atul ; HAMILTON-WRIGHT, Andrew ; CARUSONA, Andrea L ; CAMPANA, Lisa M ; TRINDER, John ; ECKERT, Danny J ; JORDAN, Amy S ; MCSHARRY, David G ; WHITE, David P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-e5834255cb9c91237ba334f0996dc7e490a6b8908bc7b7081abcdb1933973d9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Action Potentials</topic><topic>Adult</topic><topic>Airway Remodeling</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Electrodes</topic><topic>Electromyography</topic><topic>Emergency and intensive respiratory care</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoglossal Nerve - physiopathology</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morphology</topic><topic>Motor Neurons - physiology</topic><topic>Muscle function</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Neurogenesis</topic><topic>Pathogenesis</topic><topic>Respiration</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Tongue - physiopathology</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SABOISKY, Julian P</creatorcontrib><creatorcontrib>STASHUK, Daniel W</creatorcontrib><creatorcontrib>NANDEDKAR, Sanjeev</creatorcontrib><creatorcontrib>DAVID, William S</creatorcontrib><creatorcontrib>MALHOTRA, Atul</creatorcontrib><creatorcontrib>HAMILTON-WRIGHT, Andrew</creatorcontrib><creatorcontrib>CARUSONA, Andrea L</creatorcontrib><creatorcontrib>CAMPANA, Lisa M</creatorcontrib><creatorcontrib>TRINDER, John</creatorcontrib><creatorcontrib>ECKERT, Danny J</creatorcontrib><creatorcontrib>JORDAN, Amy S</creatorcontrib><creatorcontrib>MCSHARRY, David G</creatorcontrib><creatorcontrib>WHITE, David P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SABOISKY, Julian P</au><au>STASHUK, Daniel W</au><au>NANDEDKAR, Sanjeev</au><au>DAVID, William S</au><au>MALHOTRA, Atul</au><au>HAMILTON-WRIGHT, Andrew</au><au>CARUSONA, Andrea L</au><au>CAMPANA, Lisa M</au><au>TRINDER, John</au><au>ECKERT, Danny J</au><au>JORDAN, Amy S</au><au>MCSHARRY, David G</au><au>WHITE, David P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurogenic Changes in the Upper Airway of Patients with Obstructive Sleep Apnea</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>185</volume><issue>3</issue><spage>322</spage><epage>329</epage><pages>322-329</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Controversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA).
We assessed quantitative parameters related to motor unit potential (MUP) morphology derived from electromyographic (EMG) signals in patients with OSA versus control subjects and hypothesized that signs of neurogenic remodeling would be present in the patients with OSA.
Participants underwent diagnostic sleep studies to obtain apnea-hypopnea indices. Muscle activity was detected with 50-mm concentric needle electrodes. The concentric needle was positioned at more than 10 independent sites per subject, after the local anatomy of the upper airway musculature was examined by ultrasonography. All activity was quantified with subjects awake, during supine eupneic breathing while wearing a nasal mask connected to a pneumotachograph. Genioglossus EMG signals were analyzed offline by automated software (DQEMG), which extracted motor unit potential trains (MUPTs) contributed by individual motor units from the composite EMG signals. Quantitative measurements of MUP templates, including duration, peak-to-peak amplitude, area, area-to-amplitude ratio, and size index, were compared between the untreated patients with OSA and healthy control subjects.
A total of 1,655 MUPTs from patients with OSA (n = 17; AHI, 55 ± 6/h) and control subjects (n = 14; AHI, 4 ± 1/h) were extracted from the genioglossus muscle EMG signals. MUP peak-to-peak amplitudes in the patients with OSA were not different compared with the control subjects (397.5 ± 9.0 vs. 382.5 ± 10.0 μV). However, the MUPs of the patients with OSA were longer in duration (11.5 ± 0.1 vs. 10.3 ± 0.1 ms; P < 0.001) and had a larger size index (4.09 ± 0.02 vs. 3.92 ± 0.02; P < 0.001) compared with control subjects.
These results confirm and quantify the extent and existence of structural neural remodeling in OSA.</abstract><cop>New York, NY</cop><pub>American Thoracic Society</pub><pmid>22016445</pmid><doi>10.1164/rccm.201106-1058OC</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2012-02, Vol.185 (3), p.322-329 |
| issn | 1073-449X 1535-4970 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3297112 |
| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Action Potentials Adult Airway Remodeling Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Case-Control Studies Electrodes Electromyography Emergency and intensive respiratory care Female Humans Hypoglossal Nerve - physiopathology Intensive care medicine Male Medical sciences Morphology Motor Neurons - physiology Muscle function Muscle, Skeletal - innervation Muscle, Skeletal - physiopathology Neurogenesis Pathogenesis Respiration Sleep apnea Sleep Apnea, Obstructive - physiopathology Tongue - physiopathology Ultrasonic imaging |
| title | Neurogenic Changes in the Upper Airway of Patients with Obstructive Sleep Apnea |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A35%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurogenic%20Changes%20in%20the%20Upper%20Airway%20of%20Patients%20with%20Obstructive%20Sleep%20Apnea&rft.jtitle=American%20journal%20of%20respiratory%20and%20critical%20care%20medicine&rft.au=SABOISKY,%20Julian%20P&rft.date=2012-02-01&rft.volume=185&rft.issue=3&rft.spage=322&rft.epage=329&rft.pages=322-329&rft.issn=1073-449X&rft.eissn=1535-4970&rft_id=info:doi/10.1164/rccm.201106-1058OC&rft_dat=%3Cproquest_pubme%3E919955483%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=922208081&rft_id=info:pmid/22016445&rfr_iscdi=true |