Decay-accelerating factor protects human tumor cells from complement-mediated cytotoxicity in vitro

The disialoganglioside GD2 is expressed on a wide spectrum of human tumor types, including neuroblastomas and melanomas. Upon binding of 3F8, a murine monoclonal antibody (MAb) specific for GD2, neuroblastomas and some melanomas are sensitive to killing by human complement, whereas some melanomas ar...

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Veröffentlicht in:	The Journal of clinical investigation 1988-04, Vol.81 (4), p.1122-1128
Hauptverfasser:	CHEUNG, N.-K. V, WALTER, E. I, SMITH-MENSAH, W. H, RATNOFF, W. D, TYKOCINSKI, M. L, MEDOF, M. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Biological and medical sciences CD55 Antigens Complement System Proteins - physiology Cytotoxicity, Immunologic Dose-Response Relationship, Immunologic Flow Cytometry Host-tumor relations. Immunology. Biological markers Humans Immunoglobulin Fab Fragments Immunologic Techniques Medical sciences Membrane Proteins - physiology Neoplasms, Experimental - immunology Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
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