p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis
► Timely separation of the developing pituitary from the oral ectoderm relies on p21. ► p27 and p21 do not act synergistically to restrain pituitary proliferation. ► p21 is necessary to maintain basal levels of cell cycle machinery components. A delicate balance between proliferation and differentia...
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Veröffentlicht in: | Mechanisms of development 2012-01, Vol.128 (11-12), p.640-652 |
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Sprache: | eng |
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