Carboxy-terminus of CXCR7 regulates receptor localization and function

Chemokine receptor CXCR7 is essential for normal development, and this receptor promotes initiation and progression of diseases including cancer and autoimmunity. To understand normal and pathologic functions of CXCR7 and advance development of therapeutic agents, there is a need to define structura...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2012-04, Vol.44 (4), p.669-678
Hauptverfasser:	Ray, Paramita, Mihalko, Laura Anne, Coggins, Nathaniel L., Moudgil, Pranav, Ehrlich, Anna, Luker, Kathryn E., Luker, Gary D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Arrestins - metabolism atypical chemokine receptor 3 autoimmunity beta-Arrestin 2 beta-Arrestins Bioluminescence Cell Line, Tumor Cell Membrane - metabolism Chemokine chemokine CXCL12 Chemokine receptor Chemokines - metabolism dynamins Enzyme Activation Humans Intracellular Space - metabolism Ligands Luciferase mechanism of action Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism mutants plasma membrane Protein fragment complementation Protein Structure, Tertiary Protein Transport Receptors, CXCR - chemistry Receptors, CXCR - genetics Receptors, CXCR - metabolism scaffolding proteins Sequence Deletion
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