Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

Objectives Osteoarthritis is associated with cell death and extracellular matrix degradation in articular cartilage. Autophagy is an essential cellular homeostasis mechanism that was found to be deficient in ageing and osteoarthritic cartilage. This study determined whether pharmacological inhibitio...

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Veröffentlicht in:	Annals of the rheumatic diseases 2012-04, Vol.71 (4), p.575-581
Hauptverfasser:	Caramés, Beatriz, Hasegawa, Akihiko, Taniguchi, Noboru, Miyaki, Shigeru, Blanco, Francisco J, Lotz, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAMTS5 Protein Aging Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens Apoptosis Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Autophagy Autophagy - drug effects Biological and medical sciences Calcification Cartilage (articular) Cartilage diseases Cartilage, Articular - pathology Cell death Chondrocytes - metabolism Diseases of the osteoarticular system Drug Evaluation, Preclinical - methods Enzymes Gene expression Homeostasis Immunofluorescence Immunohistochemistry Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Inflammation Interleukin 1 Joint diseases Kinases Knee Ligaments Male Medical sciences Mice Mice, Inbred C57BL Miscellaneous. Osteoarticular involvement in other diseases Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism Osteoarthritis - pathology Phagocytosis Pharmacology. Drug treatments Phosphorylation Rapamycin ribosomal protein S6 Signal transduction Signal Transduction - drug effects Sirolimus - pharmacology Sirolimus - therapeutic use Synovitis Synovium TOR protein TOR Serine-Threonine Kinases - metabolism Treatment Outcome
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