In vitro and in vivo assessment of targeting lipid-based nanoparticles to the epidermal growth factor-receptor (EGFR) using a novel Heptameric ZEGFR domain

Lipid-based oil-filled nanoparticles (NPs) with a high concentration of surface-chelated nickel (Ni-NPs) were successfully prepared using a Brij 78-NTA-Ni conjugate synthesized with Brij 78 (Polyoxyethylene (20) stearyl ether) and nitrilotriacetic acid (NTA). The facile incorporation of the Brij 78-...

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Veröffentlicht in:	Journal of controlled release 2012-02, Vol.158 (1), p.63-71
Hauptverfasser:	Benhabbour, S. Rahima, Luft, J. Christopher, Kim, Dongwook, Jain, Anekant, Wadhwa, Saurabh, Parrott, Matthew C., Liu, Rihe, DeSimone, Joseph M., Mumper, Russell J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences carcinoma Cell Line, Tumor dose response Drug Carriers - administration & dosage Drug Carriers - chemistry drugs EGFR targeting epidermal growth factor receptors flow cytometry fluorescence General pharmacology Heptameric ZEGFR domain Histidine-tagged proteins Humans image analysis in vivo studies kidneys Lipid-based nanoparticles liver Medical sciences Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Mice Mice, Nude nanoparticles Neoplasms - metabolism Nickel Nickel - administration & dosage Nickel - chemistry nitrilotriacetic acid Nitrilotriacetic Acid - administration & dosage Nitrilotriacetic Acid - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Protein Structure, Tertiary Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - metabolism Succinimides - administration & dosage Succinimides - chemistry Surface-Active Agents - administration & dosage Surface-Active Agents - chemistry Tissue Distribution Triglycerides - administration & dosage Triglycerides - chemistry
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