Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)

Interactions between transforming growth factor-β (TGF-β) and Wnt are crucial to many biological processes, although specific targets, rationale for divergent outcomes (differentiation versus block of epithelial proliferation versus epithelial-mesenchymal transition (EMT)) and precise mechanisms in...

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Veröffentlicht in:	The Journal of biological chemistry 2012-03, Vol.287 (10), p.7026-7038
Hauptverfasser:	Zhou, Beiyun, Liu, Yixin, Kahn, Michael, Ann, David K., Han, Arum, Wang, Hongjun, Nguyen, Cu, Flodby, Per, Zhong, Qian, Krishnaveni, Manda S., Liebler, Janice M., Minoo, Parviz, Crandall, Edward D., Borok, Zea
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - biosynthesis beta Catenin - genetics beta Catenin - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology CBP Cell Line Cell Proliferation - drug effects Coregulator Transcription CREB-Binding Protein EMT Epithelial Cell Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Mesenchymal Transition Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Transcription Humans Lung Molecular Bases of Disease Pulmonary Fibrosis Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pyrimidinones - pharmacology Signal Transduction Smad3 Protein - genetics Smad3 Protein - metabolism Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming Growth Factor β (TGFβ) β-Catenin
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