Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice

Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Fe...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2012-01, Vol.4 (1), p.13-27
Hauptverfasser:	Streeper, Ryan S, Grueter, Carrie A, Salomonis, Nathan, Cases, Sylvaine, Levin, Malin C, Koliwad, Suneil K, Zhou, Ping, Hirschey, Mattew D, Verdin, Eric, Farese, Jr, Robert V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - physiology Aging - metabolism Animals Body Composition Bone Density - genetics Bone Density - physiology Caloric Restriction Diacylglycerol O-Acyltransferase - deficiency Diacylglycerol O-Acyltransferase - genetics Diacylglycerol O-Acyltransferase - metabolism Energy Metabolism - genetics Energy Metabolism - physiology Female Fertility Gene Expression Profiling Gene Expression Regulation Genotype Litter Size Longevity - genetics Longevity - physiology Mice Mice, Knockout Research Papers Thinness - enzymology Thinness - metabolism
Online-Zugang:	Volltext
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