Pepitome: Evaluating Improved Spectral Library Search for Identification Complementarity and Quality Assessment

Spectral libraries have emerged as a viable alternative to protein sequence databases for peptide identification. These libraries contain previously detected peptide sequences and their corresponding tandem mass spectra (MS/MS). Search engines can then identify peptides by comparing experimental MS/...

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Veröffentlicht in:	Journal of proteome research 2012-03, Vol.11 (3), p.1686-1695
Hauptverfasser:	Dasari, Surendra, Chambers, Matthew C, Martinez, Misti A, Carpenter, Kristin L, Ham, Amy-Joan L, Vega-Montoto, Lorenzo J, Tabb, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms amino acid sequences automation Blood Proteins - chemistry Cell Line data collection Databases, Protein Humans mass spectrometry Models, Statistical Neural Networks (Computer) Peptide Mapping - methods Peptide Mapping - standards peptides proteome Proteome - chemistry Proteome - genetics Proteome - metabolism proteomics quality control Reference Standards Search Engine sequence analysis Sequence Analysis, Protein - methods Serum Albumin, Bovine - chemistry Software Tandem Mass Spectrometry - methods Tandem Mass Spectrometry - standards
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