Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

The Polycomb group protein EZH2 promotes trimethylation of histone H3K27 and gene silencing. Cdk1 and Cdk2 are found to phosphorylate EZH2 and to positively regulate EZH2-mediated effects on global gene silencing, proliferation and migration. The Polycomb group (PcG) protein, enhancer of zeste homol...

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Veröffentlicht in:	Nature cell biology 2010-11, Vol.12 (11), p.1108-1114
Hauptverfasser:	Chen, Shuai, Bohrer, Laura R., Rai, Aswathy N., Pan, Yunqian, Gan, Lu, Zhou, Xianzheng, Bagchi, Anindya, Simon, Jeffrey A., Huang, Haojie
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/176/2016 631/80/458/1733 692/699/67/589/466 Acids Biology Biomedical and Life Sciences Cancer Cancer Research CDC2 Protein Kinase - genetics CDC2 Protein Kinase - metabolism Cell Biology Cell differentiation Cell growth Cyclin-Dependent Kinase 2 - genetics Cyclin-Dependent Kinase 2 - metabolism Cyclin-dependent kinases Cyclins Developmental Biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer of Zeste Homolog 2 Protein Epigenesis, Genetic - genetics Epigenetics Gene Silencing Genes HEK293 Cells Humans Kinases letter Life Sciences Observations Phosphorylation Phosphotransferases Physiology Polycomb Repressive Complex 2 Properties Proteins Stem Cells Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured
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