Association of the R67X and W303X non-sense polymorphisms in the protein Z-dependent protease inhibitor gene with idiopathic recurrent miscarriage

Protein Z-dependent protease inhibitor (ZPI) is a 72 kDa single-chain serpin which inhibits the activated coagulation factors X and XI. Two non-sense polymorphisms of ZPI, R67X and W303X, were recently identified, and were linked with a prothrombotic state. Here, we investigated the association of t...

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Veröffentlicht in:	Molecular human reproduction 2012-03, Vol.18 (3-4), p.156-160
Hauptverfasser:	ALSHAIKH, F. S, FINAN, R. R, ALMAWI, A. W, MUSTAFA, F. E, ALMAWI, W. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion Abortion, Habitual - genetics Adult Biological and medical sciences Blood coagulation. Blood cells Coagulation factor X Coagulation factors Diseases of mother, fetus and pregnancy Female Fundamental and applied biological sciences. Psychology Gene frequency Gene Frequency - genetics Gene polymorphism Genetic Predisposition to Disease - genetics Genotype Gestation Gynecology. Andrology. Obstetrics Haplotypes Haplotypes - genetics Humans Linkage disequilibrium Medical sciences Molecular and cellular biology Multivariate analysis Polymorphism, Genetic - genetics Polymorphism, Single Nucleotide - genetics Pregnancy complications Pregnancy. Fetus. Placenta Proteinase inhibitors serpins Serpins - genetics Single-nucleotide polymorphism
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