Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

The intestinal epithelium has a remarkable capacity to regenerate after injury and DNA damage. Here, we show that the integrin effector protein Focal Adhesion Kinase (FAK) is dispensable for normal intestinal homeostasis and DNA damage signaling, but is essential for intestinal regeneration followin...

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Veröffentlicht in:	Developmental cell 2010-08, Vol.19 (2), p.259-269
Hauptverfasser:	Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby J., Ridgway, Rachel A., Marsh, Victoria, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan R., Frame, Margaret C., Sansom, Owen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes CELLCYCLE Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Fundamental and applied biological sciences. Psychology Humans HUMDISEASE Intestinal Neoplasms - metabolism Intestinal Neoplasms - pathology Intestines - pathology Intestines - physiology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male Mice Mice, Inbred C57BL Molecular and cellular biology Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Regeneration Signal transduction Signal Transduction - physiology TOR Serine-Threonine Kinases Wnt Proteins - genetics Wnt Proteins - metabolism
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