PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription
Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8...
Gespeichert in:
| Veröffentlicht in: | Genes & development 2012-02, Vol.26 (4), p.325-337 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 337 |
|---|---|
| container_issue | 4 |
| container_start_page | 325 |
| container_title | Genes & development |
| container_volume | 26 |
| creator | Beck, David B Oda, Hisanobu Shen, Steven S Reinberg, Danny |
| description | Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1). It is required for maintenance of all levels of H4K20me, and, importantly, loss of PR-Set7 is catastrophic for the earliest stages of mouse embryonic development. These findings have placed PR-Set7, H4K20me, and proteins that recognize this modification as central nodes of many important pathways. In this review, we discuss the mechanisms required for regulation of PR-Set7 and H4K20me1 levels and attempt to unravel the many functions attributed to these proteins. |
| doi_str_mv | 10.1101/gad.177444.111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3289880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>926893421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-ec50ddb35bdba7674e51afbb3441a229a7054deb0084991a90d3f628c3b6195f3</originalsourceid><addsrcrecordid>eNqNkU1P3DAQhi3UChbolWPlWy9k68845lCpQm2pigSi7dly7MluqsTe2l6k_fdNWEBw68me8aNHM34ROqNkSSmhH1fWL6lSQoippgdoQaXQlRRKvUEL0mhSaV7rI3Sc8x9CSE3q-hAdMcaFlFQsUL69q35CUdgGj6_ED0ZGoBfYFlzWgF2KOadofcaxwysIcQTchwKr1JfdOXYwDNjt3ADTfZ3iGPNMuBg8hGxLH8P5g7kkG7JL_WZunaK3nR0yvHs8T9Dvr19-XV5V1zffvl9-vq6caFSpwEnifctl61uraiVAUtu1LReCWsa0VUQKDy0hjdCaWk0872rWON7WVMuOn6BPe-9m247gHYRpjMFsUj_atDPR9ub1S-jXZhXvDWeNbhoyCT48ClL8u4VczNjneWcbIG6z0axuNBeM_gfJJKETP5HLPbn_W-ie56HEzJGaKVKzj3SqZ_X7l1s8408Z8n8ZEZ28</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>922501926</pqid></control><display><type>article</type><title>PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Beck, David B ; Oda, Hisanobu ; Shen, Steven S ; Reinberg, Danny</creator><creatorcontrib>Beck, David B ; Oda, Hisanobu ; Shen, Steven S ; Reinberg, Danny</creatorcontrib><description>Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1). It is required for maintenance of all levels of H4K20me, and, importantly, loss of PR-Set7 is catastrophic for the earliest stages of mouse embryonic development. These findings have placed PR-Set7, H4K20me, and proteins that recognize this modification as central nodes of many important pathways. In this review, we discuss the mechanisms required for regulation of PR-Set7 and H4K20me1 levels and attempt to unravel the many functions attributed to these proteins.</description><identifier>ISSN: 0890-9369</identifier><identifier>EISSN: 1549-5477</identifier><identifier>DOI: 10.1101/gad.177444.111</identifier><identifier>PMID: 22345514</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Cell Cycle - physiology ; Chromosomes - metabolism ; DNA Damage ; Gene Expression Regulation ; Genome ; Histone-Lysine N-Methyltransferase - metabolism ; Histones - metabolism ; Humans ; Lysine - metabolism ; Methylation ; Review</subject><ispartof>Genes & development, 2012-02, Vol.26 (4), p.325-337</ispartof><rights>Copyright © 2012 by Cold Spring Harbor Laboratory Press 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-ec50ddb35bdba7674e51afbb3441a229a7054deb0084991a90d3f628c3b6195f3</citedby><cites>FETCH-LOGICAL-c487t-ec50ddb35bdba7674e51afbb3441a229a7054deb0084991a90d3f628c3b6195f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289880/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289880/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22345514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beck, David B</creatorcontrib><creatorcontrib>Oda, Hisanobu</creatorcontrib><creatorcontrib>Shen, Steven S</creatorcontrib><creatorcontrib>Reinberg, Danny</creatorcontrib><title>PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription</title><title>Genes & development</title><addtitle>Genes Dev</addtitle><description>Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1). It is required for maintenance of all levels of H4K20me, and, importantly, loss of PR-Set7 is catastrophic for the earliest stages of mouse embryonic development. These findings have placed PR-Set7, H4K20me, and proteins that recognize this modification as central nodes of many important pathways. In this review, we discuss the mechanisms required for regulation of PR-Set7 and H4K20me1 levels and attempt to unravel the many functions attributed to these proteins.</description><subject>Animals</subject><subject>Cell Cycle - physiology</subject><subject>Chromosomes - metabolism</subject><subject>DNA Damage</subject><subject>Gene Expression Regulation</subject><subject>Genome</subject><subject>Histone-Lysine N-Methyltransferase - metabolism</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Lysine - metabolism</subject><subject>Methylation</subject><subject>Review</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhi3UChbolWPlWy9k68845lCpQm2pigSi7dly7MluqsTe2l6k_fdNWEBw68me8aNHM34ROqNkSSmhH1fWL6lSQoippgdoQaXQlRRKvUEL0mhSaV7rI3Sc8x9CSE3q-hAdMcaFlFQsUL69q35CUdgGj6_ED0ZGoBfYFlzWgF2KOadofcaxwysIcQTchwKr1JfdOXYwDNjt3ADTfZ3iGPNMuBg8hGxLH8P5g7kkG7JL_WZunaK3nR0yvHs8T9Dvr19-XV5V1zffvl9-vq6caFSpwEnifctl61uraiVAUtu1LReCWsa0VUQKDy0hjdCaWk0872rWON7WVMuOn6BPe-9m247gHYRpjMFsUj_atDPR9ub1S-jXZhXvDWeNbhoyCT48ClL8u4VczNjneWcbIG6z0axuNBeM_gfJJKETP5HLPbn_W-ie56HEzJGaKVKzj3SqZ_X7l1s8408Z8n8ZEZ28</recordid><startdate>20120215</startdate><enddate>20120215</enddate><creator>Beck, David B</creator><creator>Oda, Hisanobu</creator><creator>Shen, Steven S</creator><creator>Reinberg, Danny</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20120215</creationdate><title>PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription</title><author>Beck, David B ; Oda, Hisanobu ; Shen, Steven S ; Reinberg, Danny</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-ec50ddb35bdba7674e51afbb3441a229a7054deb0084991a90d3f628c3b6195f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Cell Cycle - physiology</topic><topic>Chromosomes - metabolism</topic><topic>DNA Damage</topic><topic>Gene Expression Regulation</topic><topic>Genome</topic><topic>Histone-Lysine N-Methyltransferase - metabolism</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Lysine - metabolism</topic><topic>Methylation</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beck, David B</creatorcontrib><creatorcontrib>Oda, Hisanobu</creatorcontrib><creatorcontrib>Shen, Steven S</creatorcontrib><creatorcontrib>Reinberg, Danny</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beck, David B</au><au>Oda, Hisanobu</au><au>Shen, Steven S</au><au>Reinberg, Danny</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2012-02-15</date><risdate>2012</risdate><volume>26</volume><issue>4</issue><spage>325</spage><epage>337</epage><pages>325-337</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse processes ranging from the DNA damage response, mitotic condensation, and DNA replication to gene regulation. PR-Set7/Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1). It is required for maintenance of all levels of H4K20me, and, importantly, loss of PR-Set7 is catastrophic for the earliest stages of mouse embryonic development. These findings have placed PR-Set7, H4K20me, and proteins that recognize this modification as central nodes of many important pathways. In this review, we discuss the mechanisms required for regulation of PR-Set7 and H4K20me1 levels and attempt to unravel the many functions attributed to these proteins.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>22345514</pmid><doi>10.1101/gad.177444.111</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-9369 |
| ispartof | Genes & development, 2012-02, Vol.26 (4), p.325-337 |
| issn | 0890-9369 1549-5477 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3289880 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Cell Cycle - physiology Chromosomes - metabolism DNA Damage Gene Expression Regulation Genome Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Humans Lysine - metabolism Methylation Review |
| title | PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T10%3A47%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PR-Set7%20and%20H4K20me1:%20at%20the%20crossroads%20of%20genome%20integrity,%20cell%20cycle,%20chromosome%20condensation,%20and%20transcription&rft.jtitle=Genes%20&%20development&rft.au=Beck,%20David%20B&rft.date=2012-02-15&rft.volume=26&rft.issue=4&rft.spage=325&rft.epage=337&rft.pages=325-337&rft.issn=0890-9369&rft.eissn=1549-5477&rft_id=info:doi/10.1101/gad.177444.111&rft_dat=%3Cproquest_pubme%3E926893421%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=922501926&rft_id=info:pmid/22345514&rfr_iscdi=true |