Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization

Abstract The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial ce...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2012-03, Vol.425 (1), p.53-60
Hauptverfasser:	Vandermark, Erik R, Deluca, Krysta A, Gardner, Courtney R, Marker, Daniel F, Schreiner, Cynthia N, Strickland, David A, Wilton, Katelynn M, Mondal, Sumona, Woodworth, Craig D
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES BIOLOGICAL FUNCTIONS CELL PROLIFERATION Cell Transformation, Viral Cells, Cultured Cervical cancer Cervix Uteri - cytology Cervix Uteri - metabolism Cervix Uteri - virology COLONY FORMATION Defensins Epithelial Cells - metabolism Epithelial Cells - virology EPITHELIUM Female Foreskin Foreskin - cytology Foreskin - virology Gene Expression Regulation GROWTH Human papillomavirus 16 Human papillomavirus 16 - genetics Human papillomavirus 16 - growth & development Human papillomavirus 16 - metabolism Human papillomavirus 16 - pathogenicity Humans Immortalization Infectious Disease INHIBITION Male MUTANTS NEOPLASMS NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-kB Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - metabolism Oral epithelium Papillomavirus Papillomavirus E7 Proteins - genetics Papillomavirus E7 Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism TRANSCRIPTION FACTORS Transformation zone
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