Transient muscle paralysis degrades bone via rapid osteoclastogenesis

A unilateral injection of botulinum toxin A (BTxA) in the calf induces paralysis and profound loss of ipsalateral trabecular bone within days. However, the cellular mechanism underlying acute muscle paralysis‐induced bone loss (MPIBL) is poorly understood. We hypothesized that MPIBL arises via rapid...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2012-03, Vol.26 (3), p.1110-1118
Hauptverfasser:	Aliprantis, Antonios O., Stolina, Marina, Kostenuik, Paul J., Poliachik, Sandra L., Warner, Sarah E., Bain, Steven D., Gross, Ted S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone and Bones - metabolism Bone Resorption - metabolism Bone Resorption - prevention & control botulinum toxin A Botulinum Toxins, Type A - toxicity Cell Count Female Gene Deletion homeostasis Humans Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism Muscle, Skeletal - pathology NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism NFATc1 Osteoclasts - metabolism Osteoclasts - pathology Osteoprotegerin - genetics Osteoprotegerin - metabolism Osteoprotegerin - pharmacology Paralysis - chemically induced Paralysis - metabolism Quadriceps Muscle - metabolism Quadriceps Muscle - pathology RANK Ligand - metabolism RANKL Recombinant Proteins - pharmacology Research Communications Tibia - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!