Is funding source related to study reporting quality in obesity or nutrition randomized control trials in top-tier medical journals?

Background: Faithful and complete reporting of trial results is essential to the validity of the scientific literature. An earlier systematic study of randomized controlled trials (RCTs) found that industry-funded RCTs appeared to be reported with greater quality than non-industry-funded RCTs. The a...

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Veröffentlicht in:International Journal of Obesity 2012-07, Vol.36 (7), p.977-981
Hauptverfasser: Kaiser, K A, Cofield, S S, Fontaine, K R, Glasser, S P, Thabane, L, Chu, R, Ambrale, S, Dwary, A D, Kumar, A, Nayyar, G, Affuso, O, Beasley, M, Allison, D B
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container_end_page 981
container_issue 7
container_start_page 977
container_title International Journal of Obesity
container_volume 36
creator Kaiser, K A
Cofield, S S
Fontaine, K R
Glasser, S P
Thabane, L
Chu, R
Ambrale, S
Dwary, A D
Kumar, A
Nayyar, G
Affuso, O
Beasley, M
Allison, D B
description Background: Faithful and complete reporting of trial results is essential to the validity of the scientific literature. An earlier systematic study of randomized controlled trials (RCTs) found that industry-funded RCTs appeared to be reported with greater quality than non-industry-funded RCTs. The aim of this study was to examine the association between systematic differences in reporting quality and funding status (that is, industry funding vs non-industry funding) among recent obesity and nutrition RCTs published in top-tier medical journals. Methods: Thirty-eight obesity or nutrition intervention RCT articles were selected from high-profile, general medical journals ( The Lancet, Annals of Internal Medicine, JAMA and the British Medical Journal ) published between 2000 and 2007. Paired papers were selected from the same journal published in the same year, one with and the other without industry funding. The following identifying information was redacted: journal, title, authors, funding source and institution(s). Then three raters independently and blindly rated each paper according to the Chalmers method, and total reporting quality scores were calculated. Findings: The inter-rater reliability (Cronbach's alpha) was 0.82 (95% confidence interval=0.80–0.84). The total mean ( M ) and s.d. of Chalmers Index quality score (out of a possible 100) for industry-funded studies were M=84.5, s.d.=7.04 and for non-industry-funded studies they were M =79.4, s.d.=13.00. A Wilcoxon matched-pairs signed-ranks test indicates no significant rank difference in the distributions of total quality scores between funding sources, Z =−0.966, P =0.334 (two tailed). Interpretation: Recently published RCTs on nutrition and obesity that appear in top-tier journals seem to be equivalent in quality of reporting, regardless of funding source. This may be a result of recent reporting of quality statements and efforts of journal editors to raise all papers to a common standard.
doi_str_mv 10.1038/ijo.2011.207
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An earlier systematic study of randomized controlled trials (RCTs) found that industry-funded RCTs appeared to be reported with greater quality than non-industry-funded RCTs. The aim of this study was to examine the association between systematic differences in reporting quality and funding status (that is, industry funding vs non-industry funding) among recent obesity and nutrition RCTs published in top-tier medical journals. Methods: Thirty-eight obesity or nutrition intervention RCT articles were selected from high-profile, general medical journals ( The Lancet, Annals of Internal Medicine, JAMA and the British Medical Journal ) published between 2000 and 2007. Paired papers were selected from the same journal published in the same year, one with and the other without industry funding. The following identifying information was redacted: journal, title, authors, funding source and institution(s). Then three raters independently and blindly rated each paper according to the Chalmers method, and total reporting quality scores were calculated. Findings: The inter-rater reliability (Cronbach's alpha) was 0.82 (95% confidence interval=0.80–0.84). The total mean ( M ) and s.d. of Chalmers Index quality score (out of a possible 100) for industry-funded studies were M=84.5, s.d.=7.04 and for non-industry-funded studies they were M =79.4, s.d.=13.00. A Wilcoxon matched-pairs signed-ranks test indicates no significant rank difference in the distributions of total quality scores between funding sources, Z =−0.966, P =0.334 (two tailed). Interpretation: Recently published RCTs on nutrition and obesity that appear in top-tier journals seem to be equivalent in quality of reporting, regardless of funding source. 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An earlier systematic study of randomized controlled trials (RCTs) found that industry-funded RCTs appeared to be reported with greater quality than non-industry-funded RCTs. The aim of this study was to examine the association between systematic differences in reporting quality and funding status (that is, industry funding vs non-industry funding) among recent obesity and nutrition RCTs published in top-tier medical journals. Methods: Thirty-eight obesity or nutrition intervention RCT articles were selected from high-profile, general medical journals ( The Lancet, Annals of Internal Medicine, JAMA and the British Medical Journal ) published between 2000 and 2007. Paired papers were selected from the same journal published in the same year, one with and the other without industry funding. The following identifying information was redacted: journal, title, authors, funding source and institution(s). 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subjects Biological and medical sciences
Clinical trials
Dietary supplements
Epidemiology
Female
Finance
Funding
Health care
Health Promotion and Disease Prevention
Humans
Internal Medicine
Male
Medical journals
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Neurosciences
Nutrition
Obesity
original-article
Peer Review, Research
Periodicals as Topic - standards
Preventive medicine
Public Health
Randomized Controlled Trials as Topic
Reliability
Research Design
Research Support as Topic
Tournaments
Validity
title Is funding source related to study reporting quality in obesity or nutrition randomized control trials in top-tier medical journals?
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