Ephs and ephrins in cancer: Ephrin-A1 signalling
Ephrin-A1 and its primary receptor, EphA2, are involved in numerous physiological processes and have been intensely studied for their roles in malignancy. Ephrin–Eph signalling is complex on its own and is also cell-type dependent, making elucidation of the exact role of ephrin-A1 in neoplasia chall...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2012-02, Vol.23 (1), p.109-115 |
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| description | Ephrin-A1 and its primary receptor, EphA2, are involved in numerous physiological processes and have been intensely studied for their roles in malignancy. Ephrin–Eph signalling is complex on its own and is also cell-type dependent, making elucidation of the exact role of ephrin-A1 in neoplasia challenging. Multiple oncogenic signalling pathways, such as MAP/ERK and PI3K are affected by ephrin-A1, and in some cases evidence suggests the promotion of a specific pathway in one cell or cancer type and inhibition of the same pathway in another type of cell or cancer. Ephrin-A1 also plays an integral role in angiogenesis and tumor neovascularization. Until recently, studies investigating ephrins focused on the ligands as GPI-anchored proteins that required membrane anchoring or artificial clustering for Eph receptor activation. However, recent studies have demonstrated a functional role for soluble, monomeric ephrin-A1. This review will focus on various forms of ephrin-A1-specific signalling in human malignancy. |
| doi_str_mv | 10.1016/j.semcdb.2011.10.019 |
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| ispartof | Seminars in cell & developmental biology, 2012-02, Vol.23 (1), p.109-115 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Angiogenesis Animals Cell Physiological Phenomena Cytoskeleton - metabolism Endothelial Cells - metabolism Eph Ephrin Ephrin-A1 - chemistry Ephrin-A1 - metabolism Ephrin-A1 - physiology Humans Ligand Neoplasms - blood supply Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - metabolism Protein Structure, Tertiary Receptor Receptor, EphA2 - metabolism rho GTP-Binding Proteins - metabolism Signal Transduction Signalling |
| title | Ephs and ephrins in cancer: Ephrin-A1 signalling |
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