Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation

Background: The assembly of distinct proteins into tight junctions results in the formation of a continuous barrier that regulates the paracellular flux of water, ions, and small molecules across epithelia. The claudin protein family encompasses numerous major structural components of tight junction...

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Veröffentlicht in:	Developmental dynamics 2012-03, Vol.241 (3), p.583-594
Hauptverfasser:	Westmoreland, Joby J., Drosos, Yiannis, Kelly, Jacqueline, Ye, Jianming, Means, Anna L., Washington, M. Kay, Sosa-Pineda, Beatriz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transformation, Neoplastic claudin Claudins - genetics Claudins - metabolism development Epithelium - embryology Epithelium - metabolism Epithelium - pathology Humans Mice Mice, Inbred C57BL Morphogenesis Organogenesis pancreas Pancreas - embryology Pancreas - metabolism Pancreas - pathology Pancreatic Ducts - embryology Pancreatic Ducts - metabolism Pancreatic Ducts - pathology pancreatic intraepithelial neoplasia Pancreatic Neoplasms - metabolism tight junction Tumor Cells, Cultured
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