Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that accumulate during tumor formation, facilitate immune escape, and enable tumor progression. MDSCs are important contributors to the development of an immunosuppressive tumor microenvironment that blocks the action of...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-02, Vol.72 (4), p.876-886
Hauptverfasser:	LESOKHIN, Alexander M, HOHL, Tobias M, MERGHOUB, Taha, WOLCHOK, Jedd D, KITANO, Shigehisa, CORTEZ, Czrina, HIRSCHHORN-CYMERMAN, Daniel, AVOGADRI, Francesca, RIZZUTO, Gabrielle A, LAZARUS, John J, PAME, Eric G, HOUGHTON, Alan N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences CD11b Antigen - metabolism CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Female Granulocyte-Macrophage Colony-Stimulating Factor Immune Tolerance - immunology Lymphocyte Activation Medical sciences Melanoma - immunology Melanoma, Experimental - immunology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Myeloid Cells - immunology Myeloid Cells - metabolism Pharmacology. Drug treatments Receptors, CCR2 - metabolism Tumor Escape - immunology Tumor Microenvironment - immunology Tumors
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