Model System for Cell Adhesion Mediated by Weak Carbohydrate–Carbohydrate Interactions
The multivalent carbohydrate–carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mim...
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| Veröffentlicht in: | Journal of the American Chemical Society 2012-02, Vol.134 (7), p.3326-3329 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 134 |
| creator | Lorenz, Bärbel Álvarez de Cienfuegos, Luis Oelkers, Marieelen Kriemen, Ella Brand, Christian Stephan, Milena Sunnick, Eva Yüksel, Deniz Kalsani, Venkateshwarlu Kumar, Krishna Werz, Daniel B Janshoff, Andreas |
| description | The multivalent carbohydrate–carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell–cell contacts. The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. A deterministic model was used to estimate the basic energy landscape and number of participating bonds in the contact zone. |
| doi_str_mv | 10.1021/ja210304j |
| format | Article |
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An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell–cell contacts. The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. 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A deterministic model was used to estimate the basic energy landscape and number of participating bonds in the contact zone.</description><subject>Animals</subject><subject>Cell Adhesion</subject><subject>disaccharides</subject><subject>Disaccharides - chemistry</subject><subject>Disaccharides - isolation & purification</subject><subject>epitopes</subject><subject>ions</subject><subject>Lipid Bilayers - chemistry</subject><subject>microscopy</subject><subject>Microscopy, Scanning Probe</subject><subject>Porifera</subject><subject>Porifera - chemistry</subject><issn>0002-7863</issn><issn>1520-5126</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1KAzEUhYMoWqsLX0CyEXUxmp_JZLoRpPgHigsV3YXbyR07dTrRZCp05zv4hj6JkdaiIK5yb-6Xw805hGxxdsCZ4IcjEJxJlo6WSIcrwRLFRbZMOowxkeg8k2tkPYRRbFOR81WyJoToZUqnHfJw5SzW9GYaWhzT0nnax7qmx3aIoXINvUJbQYuWDqb0HuGJ9sEP3HBqfbz9eHv_2dKLpkUPRRsfhg2yUkIdcHN-dsnd6clt_zy5vD676B9fJpBK3SYlWlSQq8zqAYhclja1CoqeRUytZmClYoUCrpXUXMq4tgXJGSqBLI2l7JKjme7zZDBGW2DTeqjNs6_G4KfGQWV-T5pqaB7dq5EizwXTUWB3LuDdywRDa8ZVKKIJ0KCbBNMTkuc5171I7v1LimiwlGmmv0T3Z2jhXQgey8VCnJmvzMwis8hu__zBgvwOKQI7MwCKYEZu4pto6B9CnyHpn6s</recordid><startdate>20120222</startdate><enddate>20120222</enddate><creator>Lorenz, Bärbel</creator><creator>Álvarez de Cienfuegos, Luis</creator><creator>Oelkers, Marieelen</creator><creator>Kriemen, Ella</creator><creator>Brand, Christian</creator><creator>Stephan, Milena</creator><creator>Sunnick, Eva</creator><creator>Yüksel, Deniz</creator><creator>Kalsani, Venkateshwarlu</creator><creator>Kumar, Krishna</creator><creator>Werz, Daniel B</creator><creator>Janshoff, Andreas</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120222</creationdate><title>Model System for Cell Adhesion Mediated by Weak Carbohydrate–Carbohydrate Interactions</title><author>Lorenz, Bärbel ; Álvarez de Cienfuegos, Luis ; Oelkers, Marieelen ; Kriemen, Ella ; Brand, Christian ; Stephan, Milena ; Sunnick, Eva ; Yüksel, Deniz ; Kalsani, Venkateshwarlu ; Kumar, Krishna ; Werz, Daniel B ; Janshoff, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a437t-fede5a856d7ba283fd4d5ac9dee4d70ad350c5a17537133296da310e52e04da33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Cell Adhesion</topic><topic>disaccharides</topic><topic>Disaccharides - chemistry</topic><topic>Disaccharides - isolation & purification</topic><topic>epitopes</topic><topic>ions</topic><topic>Lipid Bilayers - chemistry</topic><topic>microscopy</topic><topic>Microscopy, Scanning Probe</topic><topic>Porifera</topic><topic>Porifera - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorenz, Bärbel</creatorcontrib><creatorcontrib>Álvarez de Cienfuegos, Luis</creatorcontrib><creatorcontrib>Oelkers, Marieelen</creatorcontrib><creatorcontrib>Kriemen, Ella</creatorcontrib><creatorcontrib>Brand, Christian</creatorcontrib><creatorcontrib>Stephan, Milena</creatorcontrib><creatorcontrib>Sunnick, Eva</creatorcontrib><creatorcontrib>Yüksel, Deniz</creatorcontrib><creatorcontrib>Kalsani, Venkateshwarlu</creatorcontrib><creatorcontrib>Kumar, Krishna</creatorcontrib><creatorcontrib>Werz, Daniel B</creatorcontrib><creatorcontrib>Janshoff, Andreas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorenz, Bärbel</au><au>Álvarez de Cienfuegos, Luis</au><au>Oelkers, Marieelen</au><au>Kriemen, Ella</au><au>Brand, Christian</au><au>Stephan, Milena</au><au>Sunnick, Eva</au><au>Yüksel, Deniz</au><au>Kalsani, Venkateshwarlu</au><au>Kumar, Krishna</au><au>Werz, Daniel B</au><au>Janshoff, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Model System for Cell Adhesion Mediated by Weak Carbohydrate–Carbohydrate Interactions</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2012-02-22</date><risdate>2012</risdate><volume>134</volume><issue>7</issue><spage>3326</spage><epage>3329</epage><pages>3326-3329</pages><issn>0002-7863</issn><issn>1520-5126</issn><eissn>1520-5126</eissn><abstract>The multivalent carbohydrate–carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell–cell contacts. The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. A deterministic model was used to estimate the basic energy landscape and number of participating bonds in the contact zone.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>22296574</pmid><doi>10.1021/ja210304j</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Cell Adhesion disaccharides Disaccharides - chemistry Disaccharides - isolation & purification epitopes ions Lipid Bilayers - chemistry microscopy Microscopy, Scanning Probe Porifera Porifera - chemistry |
| title | Model System for Cell Adhesion Mediated by Weak Carbohydrate–Carbohydrate Interactions |
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