Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria

OBJECTIVE—The coagulation-inflammation cycle has been implicated as a critical component in malaria pathogenesis. Defibrotide (DF), a mixture of DNA aptamers, displays anticoagulant, anti-inflammatory, and endothelial cell (EC)-protective activities and has been successfully used to treat comatose c...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2012-03, Vol.32 (3), p.786-798
Hauptverfasser:	Francischetti, Ivo M.B, Oliveira, Carlo J, Ostera, Graciela R, Yager, Stephanie B, Debierre-Grockiego, Françoise, Carregaro, Vanessa, Jaramillo-Gutierrez, Giovanna, Hume, Jen C.C, Jiang, Lubin, Moretz, Samuel E, Lin, Christina K, Ribeiro, José M.C, Long, Carole A, Vickers, Brandi K, Schwarz, Ralph T, Seydel, Karl B, Iacobelli, Massimo, Ackerman, Hans C, Srinivasan, Prakash, Gomes, Regis B, Wang, Xunde, Monteiro, Robson Q, Kotsyfakis, Michail, Sá-Nunes, Anderson, Waisberg, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anticoagulants - pharmacology Antimalarials - pharmacology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Coagulation - drug effects Cardiology. Vascular system Cardiovascular system Cells, Cultured Complement Activation - drug effects Cytokines - blood Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - parasitology Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - parasitology Female Glycosylphosphatidylinositols - metabolism Hemoglobins - metabolism Human health and pathology Humans Inflammation Mediators - blood Life Sciences Malaria, Cerebral - blood Malaria, Cerebral - drug therapy Malaria, Cerebral - immunology Malaria, Cerebral - parasitology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Nitric Oxide - metabolism Pharmacology. Drug treatments Plasmodium berghei - drug effects Plasmodium berghei - pathogenicity Plasmodium falciparum - drug effects Plasmodium falciparum - growth & development Plasmodium falciparum - metabolism Plasmodium falciparum - pathogenicity Platelet Aggregation - drug effects Polydeoxyribonucleotides - pharmacology Receptors, Purinergic P1 - drug effects Receptors, Purinergic P1 - metabolism Severity of Illness Index Thromboplastin - metabolism Time Factors Vasodilator agents. Cerebral vasodilators
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