Intra-Arterial Nimodipine Infusion for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage
This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients u...
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| Veröffentlicht in: | Interventional neuroradiology 2011-06, Vol.17 (2), p.169-178 |
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| creator | Cho, W-S. Kang, H-S. Kim, J.E. Kwon, O-K. Oh, C.W. Son, Y.J. Kwon, B.J. Jung, C. Han, M.H. |
| description | This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients underwent 101 sessions of intra-arterial nimodipine infusion. Angiographic response, immediate clinical response, and clinical outcome were evaluated at discharge and six months later.
Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH. |
| doi_str_mv | 10.1177/159101991101700205 |
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Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH.</description><identifier>ISSN: 1591-0199</identifier><identifier>EISSN: 2385-2011</identifier><identifier>DOI: 10.1177/159101991101700205</identifier><identifier>PMID: 21696654</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Calcium Channel Blockers - administration & dosage ; Calcium Channel Blockers - adverse effects ; Cerebral Angiography ; Female ; Follow-Up Studies ; Humans ; Infusions, Intra-Arterial ; Male ; Middle Aged ; Nimodipine - administration & dosage ; Nimodipine - adverse effects ; Original ; Retrospective Studies ; Subarachnoid Hemorrhage - complications ; Subarachnoid Hemorrhage - diagnostic imaging ; Subarachnoid Hemorrhage - drug therapy ; Treatment Outcome ; Vasospasm, Intracranial - diagnostic imaging ; Vasospasm, Intracranial - drug therapy ; Vasospasm, Intracranial - etiology</subject><ispartof>Interventional neuroradiology, 2011-06, Vol.17 (2), p.169-178</ispartof><rights>2011 SAGE Publications</rights><rights>Copyright © 2011, Centauro S.r.l. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-bc93115e105c272ca829fe2261b7a66b0b7fd3efbd6dad02892efc1b15fd0dca3</citedby><cites>FETCH-LOGICAL-c441t-bc93115e105c272ca829fe2261b7a66b0b7fd3efbd6dad02892efc1b15fd0dca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287266/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287266/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,21824,27929,27930,43626,43627,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21696654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, W-S.</creatorcontrib><creatorcontrib>Kang, H-S.</creatorcontrib><creatorcontrib>Kim, J.E.</creatorcontrib><creatorcontrib>Kwon, O-K.</creatorcontrib><creatorcontrib>Oh, C.W.</creatorcontrib><creatorcontrib>Son, Y.J.</creatorcontrib><creatorcontrib>Kwon, B.J.</creatorcontrib><creatorcontrib>Jung, C.</creatorcontrib><creatorcontrib>Han, M.H.</creatorcontrib><title>Intra-Arterial Nimodipine Infusion for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage</title><title>Interventional neuroradiology</title><addtitle>Interv Neuroradiol</addtitle><description>This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients underwent 101 sessions of intra-arterial nimodipine infusion. Angiographic response, immediate clinical response, and clinical outcome were evaluated at discharge and six months later.
Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH.</description><subject>Adult</subject><subject>Calcium Channel Blockers - administration & dosage</subject><subject>Calcium Channel Blockers - adverse effects</subject><subject>Cerebral Angiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infusions, Intra-Arterial</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nimodipine - administration & dosage</subject><subject>Nimodipine - adverse effects</subject><subject>Original</subject><subject>Retrospective Studies</subject><subject>Subarachnoid Hemorrhage - complications</subject><subject>Subarachnoid Hemorrhage - diagnostic imaging</subject><subject>Subarachnoid Hemorrhage - drug therapy</subject><subject>Treatment Outcome</subject><subject>Vasospasm, Intracranial - diagnostic imaging</subject><subject>Vasospasm, Intracranial - drug therapy</subject><subject>Vasospasm, Intracranial - etiology</subject><issn>1591-0199</issn><issn>2385-2011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gBeSP1CXk67peiOMoW4wVPDjtuRzy1iTkbTK_r0t06EI3uRc5Hnfw3kQugRyDZDnQ8gKIFAU0L45IZRkR6hP03GWUAJwjPodkHRED53FuCaEZWkBp6hHgRWMZaM-quauDjyZhFoHyzf4wVZe2a11Gs-daaL1Dhsf8FQHLUILvPHo45bHCluHn3httasj_rD1Ck-cbsIuVi313AgeuFw5bxWe6cqHsOJLfY5ODN9EffE1B-j17vZlOksWj_fz6WSRyNEI6kTIIgXINJBM0pxKPqaF0ZQyEDlnTBCRG5VqIxRTXBE6Lqg2EgRkRhEleTpAN_vebSMqraTujtyU22ArHnal57b8_ePsqlz69zKl45wy1hbQfYEMPsagzSELpOzkl3_lt6Grn1sPkW_bLTDcA7F1Ua59E1xr4b_KTzP4kM0</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Cho, W-S.</creator><creator>Kang, H-S.</creator><creator>Kim, J.E.</creator><creator>Kwon, O-K.</creator><creator>Oh, C.W.</creator><creator>Son, Y.J.</creator><creator>Kwon, B.J.</creator><creator>Jung, C.</creator><creator>Han, M.H.</creator><general>SAGE Publications</general><general>Centauro S.r.l</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20110601</creationdate><title>Intra-Arterial Nimodipine Infusion for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage</title><author>Cho, W-S. ; Kang, H-S. ; Kim, J.E. ; Kwon, O-K. ; Oh, C.W. ; Son, Y.J. ; Kwon, B.J. ; Jung, C. ; Han, M.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-bc93115e105c272ca829fe2261b7a66b0b7fd3efbd6dad02892efc1b15fd0dca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Calcium Channel Blockers - administration & dosage</topic><topic>Calcium Channel Blockers - adverse effects</topic><topic>Cerebral Angiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infusions, Intra-Arterial</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nimodipine - administration & dosage</topic><topic>Nimodipine - adverse effects</topic><topic>Original</topic><topic>Retrospective Studies</topic><topic>Subarachnoid Hemorrhage - complications</topic><topic>Subarachnoid Hemorrhage - diagnostic imaging</topic><topic>Subarachnoid Hemorrhage - drug therapy</topic><topic>Treatment Outcome</topic><topic>Vasospasm, Intracranial - diagnostic imaging</topic><topic>Vasospasm, Intracranial - drug therapy</topic><topic>Vasospasm, Intracranial - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, W-S.</creatorcontrib><creatorcontrib>Kang, H-S.</creatorcontrib><creatorcontrib>Kim, J.E.</creatorcontrib><creatorcontrib>Kwon, O-K.</creatorcontrib><creatorcontrib>Oh, C.W.</creatorcontrib><creatorcontrib>Son, Y.J.</creatorcontrib><creatorcontrib>Kwon, B.J.</creatorcontrib><creatorcontrib>Jung, C.</creatorcontrib><creatorcontrib>Han, M.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Interventional neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, W-S.</au><au>Kang, H-S.</au><au>Kim, J.E.</au><au>Kwon, O-K.</au><au>Oh, C.W.</au><au>Son, Y.J.</au><au>Kwon, B.J.</au><au>Jung, C.</au><au>Han, M.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra-Arterial Nimodipine Infusion for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage</atitle><jtitle>Interventional neuroradiology</jtitle><addtitle>Interv Neuroradiol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>17</volume><issue>2</issue><spage>169</spage><epage>178</epage><pages>169-178</pages><issn>1591-0199</issn><eissn>2385-2011</eissn><abstract>This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients underwent 101 sessions of intra-arterial nimodipine infusion. Angiographic response, immediate clinical response, and clinical outcome were evaluated at discharge and six months later.
Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21696654</pmid><doi>10.1177/159101991101700205</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Access via SAGE; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - adverse effects Cerebral Angiography Female Follow-Up Studies Humans Infusions, Intra-Arterial Male Middle Aged Nimodipine - administration & dosage Nimodipine - adverse effects Original Retrospective Studies Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - diagnostic imaging Subarachnoid Hemorrhage - drug therapy Treatment Outcome Vasospasm, Intracranial - diagnostic imaging Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - etiology |
| title | Intra-Arterial Nimodipine Infusion for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage |
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