Control of hypothalamic–pituitary–adrenal stress axis activity by the intermediate conductance calcium‐activated potassium channel, SK4

Non‐technical summary Our ability to respond to stress is critically dependent upon the release of the stress hormone adrenocorticotrophic hormone (ACTH) from corticotroph cells of the anterior pituitary gland. ACTH release is controlled by the electrical properties of corticotrophs that are determ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of physiology 2011-12, Vol.589 (24), p.5965-5986
Hauptverfasser:	Liang, Zhi, Chen, Lie, McClafferty, Heather, Lukowski, Robert, MacGregor, Duncan, King, Jonathan T., Rizzi, Sandra, Sausbier, Matthias, McCobb, David P., Knaus, Hans‐Guenther, Ruth, Peter, Shipston, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Adrenocorticotropic hormone Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - physiology Animals Argipressin Calcium Cells, Cultured Channel pores Corticosterone Corticotropin-releasing hormone Electrical properties Excitability Female Firing pattern Gene expression HEK293 Cells Homeostasis Hormones Humans Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - physiology Hypothalamus Intermediate-Conductance Calcium-Activated Potassium Channels - deficiency Intermediate-Conductance Calcium-Activated Potassium Channels - genetics Intermediate-Conductance Calcium-Activated Potassium Channels - physiology Ions Lentivirus - genetics Membrane potential Membrane Potentials Mice Mice, Knockout Molecular and Cellular Neuroendocrine system Nur77 protein Physiology Pituitary (anterior) Pituitary gland Pituitary-Adrenal System - physiology Plasma membranes Potassium channels Potassium channels (calcium-gated) Potassium conductance Restraint, Physical - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Secretion Sodium conductance Stress Stress, Physiological - physiology Transduction, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!