Mechanism of MTA1 Protein Overexpression-linked Invasion: MTA1 REGULATION OF HYALURONAN-MEDIATED MOTILITY RECEPTOR (HMMR) EXPRESSION AND FUNCTION

Even though the hyaluronan-mediated motility receptor (HMMR), a cell surface oncogenic protein, is widely up-regulated in human cancers and correlates well with cell motility and invasion, the underlying molecular and nature of its putative upstream regulation remain unknown. Here, we found for the...

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Veröffentlicht in:	The Journal of biological chemistry 2012-02, Vol.287 (8), p.5483-5491
Hauptverfasser:	Sankaran, Deivendran, Pakala, Suresh B., Nair, Vasudha S., Sirigiri, Divijendra Natha Reddy, Cyanam, Dinesh, Ha, Ngoc-Han, Li, Da-Qiang, Santhoshkumar, T.R., Pillai, M. Radhakrishna, Kumar, Rakesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Cell Line, Tumor Cell Movement - genetics Chromatin Regulation Chromatin Remodeling Coactivator Transcription Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Gene Expression Regulation, Neoplastic Gene Regulation Histone Deacetylases - genetics HMMR Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Invasion JNK Mitogen-Activated Protein Kinases - metabolism Mice Migration Molecular Bases of Disease MTA1 Neoplasm Invasiveness Repressor Proteins - genetics RNA Polymerase II - metabolism Trans-Activators Transcription, Genetic - genetics
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