Drug-Drug Interaction Analysis of Pyronaridine/Artesunate and Ritonavir in Healthy Volunteers

A multiple dose, parallel group study was conducted to assess for a drug-drug interaction between the pyronaridine/artesunate (PA) combination antimalarial and ritonavir. Thirty-four healthy adults were randomized (1:1) to receive PA for 3 days or PA with ritonavir (100 mg twice daily for 17 days, P...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 2012-03, Vol.86 (3), p.489-495
Hauptverfasser:	MORRIS, Carrie A, LOPEZ-LAZARO, Luis, JUNG, Donald, METHANEETHORN, Janthima, DUPARC, Stephan, BORGHINI-FUHRER, Isabelle, POKORNY, Rolf, SHIN, Chang-Sik, FLECKENSTEIN, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - administration & dosage Antimalarials - pharmacokinetics Antiparasitic agents Antiviral agents Area Under Curve Artemisinins - administration & dosage Artemisinins - pharmacokinetics Artesunate Biological and medical sciences Drug Interactions Female HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - pharmacokinetics Humans Infectious diseases Male Medical sciences Middle Aged Naphthyridines - administration & dosage Naphthyridines - pharmacokinetics Pharmacology. Drug treatments Ritonavir - administration & dosage Ritonavir - pharmacokinetics Young Adult
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