Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function

Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secretion. Mice lacking β-cell ABCA1 have increased islet expression of ABCG1, another c...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2012-03, Vol.61 (3), p.659-664
Hauptverfasser:	KRUIT, Janine K, WIJESEKARA, Nadeeja, BRUNHAM, Liam R, VERCHERE, C. Bruce, HAYDEN, Michael R, WESTWELL-ROPER, Clara, VANMIERLO, Tim, DE HAAN, Willeke, BHATTACHARJEE, Alpana, RENMEI TANG, WELLINGTON, Cheryl L, LÜTJOHANN, Dieter, JOHNSON, James D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - physiology Biological and medical sciences Cholesterol - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Genetic aspects Glucose Intolerance - etiology Homeostasis Inflammation - etiology Insulin-Secreting Cells - physiology Interleukin-1beta - genetics Islet Studies Islets of Langerhans - metabolism Lipoproteins - physiology Macrophages - physiology Medical sciences Mice Mice, Inbred C57BL Pancreatic beta cells Physiological aspects Transcription Factor CHOP - physiology
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