Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes

We assessed the effects of non-HLA gene polymorphisms on the risk of islet autoimmunity (IA) and progression to type 1 diabetes in the Diabetes Autoimmunity Study in the Young. A total of 1,743 non-Hispanic, white children were included: 861 first-degree relatives and 882 general population children...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2012-03, Vol.61 (3), p.753-758
Hauptverfasser:	STECK, Andrea K, WONG, Randall, WAGNER, Brandie, JOHNSON, Kelly, EDWIN LIU, ROMANOS, Jihane, WIJMENGA, Cisca, NORRIS, Jill M, EISENBARTH, George S, REWERS, Marian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Autoimmunity Biological and medical sciences Children Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Families & family life Gene polymorphism Genes Genetic polymorphisms Genetics/Genomes/Proteomics/Metabolomics Genomes Genotype Genotype & phenotype Histocompatibility antigen HLA HLA-DQ Antigens - genetics HLA-DR Antigens - genetics Humans Islets of Langerhans Islets of Langerhans - immunology Medical sciences Medical screening Polymorphism Polymorphism, Single Nucleotide Population genetics Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics Protein-tyrosine-phosphatase PTPN2 protein Regression analysis Replication Risk Factors Risk groups Type 1 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!