Transcription-induced conformational change in a topologically closed DNA domain

We have tested in vitro the occurrence of a B-to-Z transition in a region of alternating purines and pyrimidines as a consequence of transcription-induced negative supercoiling. By using a monoclonal antibody as a specific Z-DNA stabilizing agent, we demonstrate that the formation of left-handed DNA...

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Veröffentlicht in:	Nucleic acids research 1991-06, Vol.19 (11), p.2941-2946
Hauptverfasser:	DROGE, P, NORDHEIM, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Biological and medical sciences Chromatography, Affinity DNA - chemistry DNA Topoisomerases, Type I - chemistry DNA, Superhelical - chemistry Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Molecular and cellular biology Molecular genetics Nucleic Acid Conformation Plasmids Templates, Genetic Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing
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