Aptamers and the RNA world, past and present
Aptamers and the SELEX process were discovered over two decades ago. These discoveries have spawned a productive academic and commercial industry. The collective results provide insights into biology, past and present, through an in vitro evolutionary exploration of the nature of nucleic acids and t...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in biology 2012-03, Vol.4 (3), p.a003582-a003582 |
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| container_issue | 3 |
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| container_title | Cold Spring Harbor perspectives in biology |
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| creator | Gold, Larry Janjic, Nebojsa Jarvis, Thale Schneider, Dan Walker, Jeffrey J Wilcox, Sheri K Zichi, Dom |
| description | Aptamers and the SELEX process were discovered over two decades ago. These discoveries have spawned a productive academic and commercial industry. The collective results provide insights into biology, past and present, through an in vitro evolutionary exploration of the nature of nucleic acids and their potential roles in ancient life. Aptamers have helped usher in an RNA renaissance. Here we explore some of the evolution of the aptamer field and the insights it has provided for conceptualizing an RNA world, from its nascence to our current endeavor employing aptamers in human proteomics to discover biomarkers of health and disease. |
| doi_str_mv | 10.1101/cshperspect.a003582 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1943-0264 |
| ispartof | Cold Spring Harbor perspectives in biology, 2012-03, Vol.4 (3), p.a003582-a003582 |
| issn | 1943-0264 1943-0264 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aptamers, Nucleotide - chemistry Biomarkers - blood Biomarkers - chemistry Concepts History, 20th Century Humans Proteomics - methods RNA - chemistry RNA - physiology SELEX Aptamer Technique - history |
| title | Aptamers and the RNA world, past and present |
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