Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian Cells

Cytokinesis in mammalian cells requires actin assembly at the equatorial region. Although functions of RhoA in this process have been well established, additional mechanisms are likely involved. We have examined if Cdc42 is involved in actin assembly during cytokinesis. Depletion of Cdc42 had no app...

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Veröffentlicht in:	Experimental cell research 2011-10, Vol.317 (16), p.2384-2389
Hauptverfasser:	Zhu, Xiaodong, Wang, Junxia, Moriguchi, Kazuki, Liow, Lu Ting, Ahmed, Sohail, Kaverina, Irina, Murata-Hori, Maki
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Actin Cytoskeleton - pathology Actins - genetics Actins - metabolism Adherent mammalian cells Animals Cdc42 cdc42 GTP-Binding Protein - deficiency cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell adhesion & migration Cell Line Cell Shape Cellular biology Cytokines Cytokinesis Cytokinesis - physiology Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial Cells - pathology Gene expression Kidney - cytology Microscopy, Phase-Contrast Mitosis - physiology Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism rhoA GTP-Binding Protein - metabolism RNA, Small Interfering - genetics Time-Lapse Imaging Transfection
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