Induction of Intracellular Calcium Concentration by Environmental Benzo(a)pyrene Involves a β2-Adrenergic Receptor/Adenylyl Cyclase/Epac-1/Inositol 1,4,5-Trisphosphate Pathway in Endothelial Cells

Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). These chemicals trigger an early and transient increase of intracellular calcium concentration ([Ca2+]i), required...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2012-02, Vol.287 (6), p.4041-4052
Hauptverfasser:	Mayati, Abdullah, Levoin, Nicolas, Paris, Hervé, N'Diaye, Monique, Courtois, Arnaud, Uriac, Philippe, Lagadic-Gossmann, Dominique, Fardel, Olivier, Le Ferrec, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - genetics Adenylyl Cyclases - metabolism Air Pollutants - pharmacology Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism benzo(a)pyrene Benzo(a)pyrene - pharmacology Biochemistry, Molecular Biology Calcium Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - genetics Camp Cell signaling Cell surface receptor Cytochrome P-450 CYP1B1 Endothelial Cells - metabolism G protein-coupled receptors (GPCRs) Gene Knockdown Techniques Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism HEK293 Cells Humans Inositol 1,4,5-Trisphosphate - genetics Inositol 1,4,5-Trisphosphate - metabolism Life Sciences polycyclic aromatic hydrocarbon Protein Binding Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Signal Transduction β2-adrenergic receptor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!