Hypercholesterolemia Induces Up-regulation of KACh Cardiac Currents via a Mechanism Independent of Phosphatidylinositol 4,5-Bisphosphate and Gβγ

Hypercholesterolemia is a well-known risk factor for cardiovascular disease. In the heart, activation of KACh mediates the vagal (parasympathetic) negative chronotropic effect on heart rate. Yet, the effect of cholesterol on KACh is unknown. Here we show that cholesterol plays a critical role in mod...

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Veröffentlicht in:	The Journal of biological chemistry 2012-02, Vol.287 (7), p.4925-4935
Hauptverfasser:	Deng, Wu, Bukiya, Anna N., Rodríguez-Menchaca, Aldo A., Zhang, Zhe, Baumgarten, Clive M., Logothetis, Diomedes E., Levitan, Irena, Rosenhouse-Dantsker, Avia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Cardiomyocytes Cholesterol Cholesterol - metabolism Dietary Fats - adverse effects Dietary Fats - pharmacology G Protein-Coupled Inwardly-Rectifying Potassium Channels - biosynthesis G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics Heart Atria - metabolism Heart Atria - pathology Hyperhomocysteinemia - chemically induced Hyperhomocysteinemia - genetics Hyperhomocysteinemia - metabolism IK1 Ion Channels KACh Lipids Membrane Biology Membrane Lipids Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Phosphatidylinositol 4,5-Diphosphate - genetics Phosphatidylinositol 4,5-Diphosphate - metabolism Potassium Channels Rabbits Up-Regulation Xenopus laevis
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