Protein Modification by Deamidation Indicates Variations in Joint Extracellular Matrix Turnover

As extracellular proteins age, they undergo and accumulate nonenzymatic post-translational modifications that cannot be repaired. We hypothesized that these could be used to systemically monitor loss of extracellular matrix due to chronic arthritic diseases such as osteoarthritis (OA). To test this,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2012-02, Vol.287 (7), p.4640-4651
Hauptverfasser:	Catterall, Jonathan B., Hsueh, Ming F., Stabler, Thomas V., McCudden, Christopher R., Bolognesi, Michael, Zura, Robert, Jordan, Joanne M., Renner, Jordan B., Feng, Sheng, Kraus, Virginia B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging Antibodies, Monoclonal, Murine-Derived - chemistry Arthroplasty, Replacement, Hip Arthroplasty, Replacement, Knee Asparagine - metabolism Aspartate Aspartic Acid - metabolism Cartilage - metabolism Cartilage - pathology Cartilage - surgery Cartilage Biology Cartilage Oligomeric Matrix Protein Cohort Studies COMP Enzyme-Linked Immunosorbent Assay Extracellular Matrix Extracellular Matrix Proteins Extracellular Matrix Proteins - metabolism Female Glycobiology and Extracellular Matrices Glycoproteins - metabolism Humans Male Mass Spectrometry Matrilin Proteins Middle Aged Osteoarthritis Osteoarthritis, Hip - metabolism Osteoarthritis, Hip - pathology Osteoarthritis, Hip - surgery Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Osteoarthritis, Knee - surgery Protein Deamidation Protein Processing, Post-Translational Protein Turnover
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!