Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells

Somatic mutation of ten-eleven translocation 2 ( TET2 ) gene is frequently found in human myeloid malignancies. Recent reports showed that loss of Tet2 led to pleiotropic hematopoietic abnormalities including increased competitive repopulating capacity of bone marrow (BM) HSCs and myeloid transforma...

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Veröffentlicht in:	Scientific reports 2012-02, Vol.2 (1), p.273-273, Article 273
Hauptverfasser:	Kunimoto, Hiroyoshi, Fukuchi, Yumi, Sakurai, Masatoshi, Sadahira, Ken, Ikeda, Yasuo, Okamoto, Shinichiro, Nakajima, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/142 631/337/176 631/532 692/308 Ablation Animals Blood cells Bone marrow Brain cancer c-Kit protein Cell Differentiation - genetics Cell self-renewal Competition Competitive advantage DNA-Binding Proteins - genetics Epigenetics Fetuses Flow Cytometry Genetic transformation Genomes Hematopoietic Stem Cells - cytology Hepatocytes Homeostasis Humanities and Social Sciences Leukemia Liver Liver - cytology Liver - embryology Mice Mice, Inbred C57BL multidisciplinary Mutation Proto-Oncogene Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Science Stem cells Translocation Transplantation Transplants & implants
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