Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
► Hydrophobic polymers are extensively used as matrix former in controlled drug delivery. ► We have synthesized a new hydrophobic polymer using acetylation of native moth bean starch. ► The hydrophobic polymer was evaluated as controlled release excipient for pharmaceutical formulation development....
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| Veröffentlicht in: | International journal of biological macromolecules 2012-03, Vol.50 (2), p.362-368 |
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| container_title | International journal of biological macromolecules |
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| creator | Singh, Akhilesh V. Nath, Lila K. |
| description | ► Hydrophobic polymers are extensively used as matrix former in controlled drug delivery. ► We have synthesized a new hydrophobic polymer using acetylation of native moth bean starch. ► The hydrophobic polymer was evaluated as controlled release excipient for pharmaceutical formulation development. ► The results revealed that the acetylated moth bean starch can be used as controlled release polymer.
The present investigation concerns with the development of controlled release tablets of lamivudine using acetylated moth bean starch. The acetylated starch was synthesized with acetic anhydride in pyridine medium. The acetylated moth bean starch was tested for acute toxicity and drug–excipient compatibility study. The formulations were evaluated for physical characteristics like hardness, friability, % drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi kinetic model and the release mechanism study proved that the formulation showed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (Tmax, Cmax, AUC, Vd, T1/2 and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir®, which proved controlled release potential of acetylated moth bean starch. |
| doi_str_mv | 10.1016/j.ijbiomac.2011.12.011 |
| format | Article |
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The present investigation concerns with the development of controlled release tablets of lamivudine using acetylated moth bean starch. The acetylated starch was synthesized with acetic anhydride in pyridine medium. The acetylated moth bean starch was tested for acute toxicity and drug–excipient compatibility study. The formulations were evaluated for physical characteristics like hardness, friability, % drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi kinetic model and the release mechanism study proved that the formulation showed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (Tmax, Cmax, AUC, Vd, T1/2 and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir®, which proved controlled release potential of acetylated moth bean starch.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2011.12.011</identifier><identifier>PMID: 22210486</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acetic anhydride ; Acetylation ; Acute toxicity ; Animals ; Anti-HIV Agents - administration & dosage ; Anti-HIV Agents - pharmacokinetics ; Anti-HIV Agents - pharmacology ; Beans ; Biological Availability ; Chemistry, Pharmaceutical ; Controlled release ; Controlled release tablet ; Delayed-Action Preparations - administration & dosage ; Delayed-Action Preparations - pharmacology ; Diffusion ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; Drug Carriers - toxicity ; Drug delivery ; Drug Stability ; drugs ; Excipients - chemistry ; Female ; hardness ; Kinetics ; Lamivudine ; Lamivudine - administration & dosage ; Lamivudine - pharmacokinetics ; Lamivudine - pharmacology ; Macromolecules ; Male ; Moth bean starch ; Pharmacokinetics ; Physical characteristics ; pyridines ; Rabbits ; Sexually-transmitted diseases ; Starch ; Starch - chemical synthesis ; Starch - chemistry ; Starch - toxicity ; Tablets ; Vigna aconitifolia</subject><ispartof>International journal of biological macromolecules, 2012-03, Vol.50 (2), p.362-368</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><rights>2012 Elsevier B.V. 2012 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-53a46d7bc8c92f0d75cfb5ebdcb32df6ea4113438ba3d681b31683481b24a0a13</citedby><cites>FETCH-LOGICAL-c536t-53a46d7bc8c92f0d75cfb5ebdcb32df6ea4113438ba3d681b31683481b24a0a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813011004727$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22210486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Akhilesh V.</creatorcontrib><creatorcontrib>Nath, Lila K.</creatorcontrib><title>Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>► Hydrophobic polymers are extensively used as matrix former in controlled drug delivery. ► We have synthesized a new hydrophobic polymer using acetylation of native moth bean starch. ► The hydrophobic polymer was evaluated as controlled release excipient for pharmaceutical formulation development. ► The results revealed that the acetylated moth bean starch can be used as controlled release polymer.
The present investigation concerns with the development of controlled release tablets of lamivudine using acetylated moth bean starch. The acetylated starch was synthesized with acetic anhydride in pyridine medium. The acetylated moth bean starch was tested for acute toxicity and drug–excipient compatibility study. The formulations were evaluated for physical characteristics like hardness, friability, % drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi kinetic model and the release mechanism study proved that the formulation showed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (Tmax, Cmax, AUC, Vd, T1/2 and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir®, which proved controlled release potential of acetylated moth bean starch.</description><subject>Acetic anhydride</subject><subject>Acetylation</subject><subject>Acute toxicity</subject><subject>Animals</subject><subject>Anti-HIV Agents - administration & dosage</subject><subject>Anti-HIV Agents - pharmacokinetics</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Beans</subject><subject>Biological Availability</subject><subject>Chemistry, Pharmaceutical</subject><subject>Controlled release</subject><subject>Controlled release tablet</subject><subject>Delayed-Action Preparations - administration & dosage</subject><subject>Delayed-Action Preparations - pharmacology</subject><subject>Diffusion</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - toxicity</subject><subject>Drug delivery</subject><subject>Drug Stability</subject><subject>drugs</subject><subject>Excipients - chemistry</subject><subject>Female</subject><subject>hardness</subject><subject>Kinetics</subject><subject>Lamivudine</subject><subject>Lamivudine - administration & dosage</subject><subject>Lamivudine - pharmacokinetics</subject><subject>Lamivudine - pharmacology</subject><subject>Macromolecules</subject><subject>Male</subject><subject>Moth bean starch</subject><subject>Pharmacokinetics</subject><subject>Physical characteristics</subject><subject>pyridines</subject><subject>Rabbits</subject><subject>Sexually-transmitted diseases</subject><subject>Starch</subject><subject>Starch - chemical synthesis</subject><subject>Starch - chemistry</subject><subject>Starch - toxicity</subject><subject>Tablets</subject><subject>Vigna aconitifolia</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvLX6h85JLgsROv94JAVWmRKnGAnq2JPel6lcTFTlbaf49X21Zw6ulZ9jdvxvMYuwRRgwD9eVeHXRfiiK6WAqAGWRd5w1Zg1ptKCKHespWABioDSpyxDznvyq1uwbxnZ1JKEI3RK_breo_DgnOIE489R0fzYcCZPB_jvOUd4cTzjMltOWaO3GFKgRLvY-IuTnOKw1Bgn5YH7mkIe0qHC_auxyHTxyc9Z_ffr39f3VZ3P29-XH27q1yr9Fy1Chvt150zbiN74det67uWOu86JX2vCRsA1SjTofLaQKdAG9WUg2xQIKhz9uXk-7h0I3lHZRwc7GMKI6aDjRjs_y9T2NqHuLdKGoCNLAafngxS_LNQnu0YsqNhwInikq0Ux5XpjVKvoqCkMoU3bUH1CXUp5pyof5kIhD2GZ3f2OTx7DM-CtEVK4eW__3kpe06rAF9PAJWt7ksMNrtAkyMfErnZ-hhe6_EXZDyvhA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Singh, Akhilesh V.</creator><creator>Nath, Lila K.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery</title><author>Singh, Akhilesh V. ; Nath, Lila K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-53a46d7bc8c92f0d75cfb5ebdcb32df6ea4113438ba3d681b31683481b24a0a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acetic anhydride</topic><topic>Acetylation</topic><topic>Acute toxicity</topic><topic>Animals</topic><topic>Anti-HIV Agents - administration & dosage</topic><topic>Anti-HIV Agents - pharmacokinetics</topic><topic>Anti-HIV Agents - pharmacology</topic><topic>Beans</topic><topic>Biological Availability</topic><topic>Chemistry, Pharmaceutical</topic><topic>Controlled release</topic><topic>Controlled release tablet</topic><topic>Delayed-Action Preparations - administration & dosage</topic><topic>Delayed-Action Preparations - pharmacology</topic><topic>Diffusion</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - toxicity</topic><topic>Drug delivery</topic><topic>Drug Stability</topic><topic>drugs</topic><topic>Excipients - chemistry</topic><topic>Female</topic><topic>hardness</topic><topic>Kinetics</topic><topic>Lamivudine</topic><topic>Lamivudine - administration & dosage</topic><topic>Lamivudine - pharmacokinetics</topic><topic>Lamivudine - pharmacology</topic><topic>Macromolecules</topic><topic>Male</topic><topic>Moth bean starch</topic><topic>Pharmacokinetics</topic><topic>Physical characteristics</topic><topic>pyridines</topic><topic>Rabbits</topic><topic>Sexually-transmitted diseases</topic><topic>Starch</topic><topic>Starch - chemical synthesis</topic><topic>Starch - chemistry</topic><topic>Starch - toxicity</topic><topic>Tablets</topic><topic>Vigna aconitifolia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Akhilesh V.</creatorcontrib><creatorcontrib>Nath, Lila K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Akhilesh V.</au><au>Nath, Lila K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>50</volume><issue>2</issue><spage>362</spage><epage>368</epage><pages>362-368</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>► Hydrophobic polymers are extensively used as matrix former in controlled drug delivery. ► We have synthesized a new hydrophobic polymer using acetylation of native moth bean starch. ► The hydrophobic polymer was evaluated as controlled release excipient for pharmaceutical formulation development. ► The results revealed that the acetylated moth bean starch can be used as controlled release polymer.
The present investigation concerns with the development of controlled release tablets of lamivudine using acetylated moth bean starch. The acetylated starch was synthesized with acetic anhydride in pyridine medium. The acetylated moth bean starch was tested for acute toxicity and drug–excipient compatibility study. The formulations were evaluated for physical characteristics like hardness, friability, % drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi kinetic model and the release mechanism study proved that the formulation showed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (Tmax, Cmax, AUC, Vd, T1/2 and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir®, which proved controlled release potential of acetylated moth bean starch.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22210486</pmid><doi>10.1016/j.ijbiomac.2011.12.011</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of biological macromolecules, 2012-03, Vol.50 (2), p.362-368 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetic anhydride Acetylation Acute toxicity Animals Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - pharmacology Beans Biological Availability Chemistry, Pharmaceutical Controlled release Controlled release tablet Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - pharmacology Diffusion Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - toxicity Drug delivery Drug Stability drugs Excipients - chemistry Female hardness Kinetics Lamivudine Lamivudine - administration & dosage Lamivudine - pharmacokinetics Lamivudine - pharmacology Macromolecules Male Moth bean starch Pharmacokinetics Physical characteristics pyridines Rabbits Sexually-transmitted diseases Starch Starch - chemical synthesis Starch - chemistry Starch - toxicity Tablets Vigna aconitifolia |
| title | Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery |
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