Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5

Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates the expression of multiple TLR-induced genes in macrophages independently of osm...

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Veröffentlicht in:	The Journal of experimental medicine 2012-02, Vol.209 (2), p.379-393
Hauptverfasser:	Buxadé, Maria, Lunazzi, Giulia, Minguillón, Jordi, Iborra, Salvador, Berga-Bolaños, Rosa, Del Val, Margarita, Aramburu, José, López-Rodríguez, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin Immunoprecipitation Cèl·lules T DNA Primers - genetics Factors de transcripció Flow Cytometry Gene Expression Regulation - genetics Gene Expression Regulation - immunology Gene Regulatory Networks - genetics Gene Regulatory Networks - immunology I-kappa B Kinase - metabolism Immunoblotting Interleukin-6 - metabolism Leishmania - immunology Leishmania major Luciferases Macrophages - metabolism Metabolisme Mice Mice, Knockout Microarray Analysis Nitric Oxide Synthase Type II - metabolism Nitrites - metabolism Plasmids - genetics Receptors Regulació genètica Toll-Like Receptors - metabolism Transcription Factors - genetics Transcription Factors - metabolism Tumor Necrosis Factor-alpha - metabolism
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