Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

Intracellular macrophage migration inhibitory factor (MIF) often becomes stabilized in human cancer cells. MIF can promote tumor cell survival, and elevated MIF protein correlates with tumor aggressiveness and poor prognosis. However, the molecular mechanism facilitating MIF stabilization in tumors...

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Veröffentlicht in:	The Journal of experimental medicine 2012-02, Vol.209 (2), p.275-289
Hauptverfasser:	Schulz, Ramona, Marchenko, Natalia D, Holembowski, Lena, Fingerle-Rowson, Günter, Pesic, Marina, Zender, Lars, Dobbelstein, Matthias, Moll, Ute M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Apoptosis - physiology Benzoquinones - pharmacology Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Cell Proliferation - drug effects Densitometry DNA Primers - genetics Female Flow Cytometry Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Image Processing, Computer-Assisted Immunoblotting Immunohistochemistry Immunoprecipitation Lactams, Macrocyclic - pharmacology Macrophage Migration-Inhibitory Factors - metabolism Mice Mice, Transgenic Multiprotein Complexes - metabolism Protein Stability Real-Time Polymerase Chain Reaction Receptor, ErbB-2 RNA, Small Interfering - genetics Ubiquitin-Protein Ligases - metabolism
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