cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase

Cholestatic liver disorders are accompanied by the hepatic accumulation of cytotoxic bile acids that induce cell death. Increases in cAMP protect hepatocytes from bile acid-induced apoptosis by a cAMP-guanine exchange factor (cAMP-GEF)/phosphoinositide-3-kinase (PI3K)/Akt pathway. The aim of these s...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2011-08, Vol.301 (2), p.G385-G400
Hauptverfasser:	Johnston, A, Ponzetti, K, Anwer, M S, Webster, C R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Bile Acids and Salts - pharmacology Carcinoma, Hepatocellular Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Cyclic AMP - physiology Cytoprotection Endoplasmic Reticulum - physiology Glycochenodeoxycholic Acid - physiology Glycogen Synthase Kinase 3 - physiology Guanine Nucleotide Exchange Factors - physiology Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - physiology Humans JNK Mitogen-Activated Protein Kinases - metabolism Liver and Biliary Tract Male Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt rap1 GTP-Binding Proteins - physiology Rats Rats, Wistar Signal Transduction - physiology Stress, Physiological - physiology Thionucleotides Tumor Cells, Cultured
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