Insulin Transactivator MafA Regulates Intrathymic Expression of Insulin and Affects Susceptibility to Type 1 Diabetes

Tissue-specific self-antigens are ectopically expressed within the thymus and play an important role in the induction of central tolerance. Insulin is expressed in both pancreatic islets and the thymus and is considered to be the primary antigen for type 1 diabetes. Here, we report the role of the i...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2010-10, Vol.59 (10), p.2579-2587
Hauptverfasser:	NOSO, Shinsuke, KATAOKA, Kohsuke, IKEGAMI, Hiroshi, KAWABATA, Yumiko, BABAYA, Naru, HIROMINE, Yoshihisa, YAMAJI, Kaori, FUJISAWA, Tomomi, ARAMATA, Shinsaku, KUDO, Takashi, TAKAHASHI, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	AIRE Protein Animals Antibodies Antigens Autoimmune diseases Biological and medical sciences Development and progression Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Disease DNA-Binding Proteins - genetics Dosage and administration Drug therapy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gene Expression Profiling Gene Expression Regulation Genes Genetic Predisposition to Disease Genetic regulation Genetic susceptibility Humans Immunohistochemistry Immunology and Transplantation Insulin Insulin - genetics Islets of Langerhans - cytology Islets of Langerhans - physiology Laboratories Maf Transcription Factors, Large - deficiency Maf Transcription Factors, Large - genetics Maf Transcription Factors, Large - physiology Male Medical sciences Mice Mice, Inbred NOD Mice, Knockout Promoter Regions, Genetic Regulation Research design Reverse Transcriptase Polymerase Chain Reaction Risk factors Thymus gland Thymus Gland - physiology Thyroid gland Transcription Factors - genetics Transcription, Genetic Type 1 diabetes
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