Chronic perinatal hypoxia reduces glutamate-aspartate transporter function in astrocytes through the Janus kinase/signal transducer and activator of transcription pathway

The cellular and molecular mechanisms that govern the response of the perinatal brain to injury remain largely unexplored. We investigated the role of white matter astrocytes in a rodent model of diffuse white matter injury produced by exposing neonatal mice to chronic hypoxia-a paradigm that mimics...

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Veröffentlicht in:	The Journal of neuroscience 2011-12, Vol.31 (49), p.17864-17871
Hauptverfasser:	Raymond, Matthew, Li, Peijun, Mangin, Jean-Marie, Huntsman, Molly, Gallo, Vittorio
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Amino Acid Transport System X-AG - metabolism Animals Animals, Newborn Aspartic Acid - metabolism Astrocytes - metabolism Bromodeoxyuridine - metabolism Cell Count - methods Cells, Cultured Disease Models, Animal Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Expression Regulation - physiology Glial Fibrillary Acidic Protein - genetics Gliosis - etiology Gliosis - metabolism Gliosis - pathology Green Fluorescent Proteins - genetics Hypoxia - pathology Intermediate Filament Proteins - metabolism Janus Kinases - metabolism Male Mice Mice, Transgenic Nerve Tissue Proteins - metabolism Nestin Signal Transduction - drug effects Signal Transduction - physiology STAT Transcription Factors - metabolism Tritium - metabolism Tyrphostins - pharmacology
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