Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria

Summary The ESX‐1 secretion system is required for pathogenicity of Mycobacterium tuberculosis (Mtb). Despite considerable research, little is known about the structural components of ESX‐1, or how these proteins are assembled into the active secretion apparatus. Here, we exploit the functionally re...

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Veröffentlicht in:	Molecular microbiology 2012-02, Vol.83 (3), p.654-664
Hauptverfasser:	Wirth, Samantha E., Krywy, Janet A., Aldridge, Bree B., Fortune, Sarah M., Fernandez-Suarez, Marta, Gray, Todd A., Derbyshire, Keith M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial proteins Bacterial Proteins - metabolism Bacterial Secretion Systems Bacteriology Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene expression Gram-positive bacteria Microbiology Miscellaneous Mutation Mycobacterium smegmatis Mycobacterium smegmatis - genetics Mycobacterium smegmatis - metabolism Mycobacterium smegmatis - pathogenicity Mycobacterium tuberculosis Operon Protein Transport Virulence
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