Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) demonstrates a global down-regulation of miR-15a and miR-16 and a selective silencing of the related miR-29b in aggressive disease. Deletions in chromosome 13 [del(13q14)] partially account for the loss of expression of miR-15a and miR-16, but the mechanisms by whi...

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Veröffentlicht in:	Blood 2012-02, Vol.119 (5), p.1162-1172
Hauptverfasser:	Sampath, Deepa, Liu, Chaomei, Vasan, Karthik, Sulda, Melanie, Puduvalli, Vinay K., Wierda, William G., Keating, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Benzamides - pharmacology Biological and medical sciences Female Gene Expression Regulation, Leukemic - drug effects Gene Silencing - drug effects Gene Silencing - physiology Hematologic and hematopoietic diseases Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - physiology Humans Hydroxamic Acids - pharmacology Indoles Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoid Neoplasia Male Medical sciences MicroRNAs - genetics Panobinostat Primary Cell Culture Pyridines - pharmacology Tumor Cells, Cultured
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